Nakata Yuuki, Furuya Shinji, Takiguchi Kouichi, Ashizawa Naoki, Shimizu Hiroki, Akaike Hidenori, Hosomura Naohiro, Kawaguchi Yoshihiko, Amemiya Hidetake, Sudo Makoto, Kawaida Hiromichi, Inoue Shingo, Kono Hiroshi, Ichikawa Daisuke
First Dept. of Surgery, Faculty of Medicine, University of Yamanashi.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2389-2391.
We examined the relationship between immune and nutritional indices and the outcome of colorectal cancer patients at our hospital. We retrospectively analyzed 196 patients with pStage Ⅱand Ⅲcolorectal cancer who underwent curative surgery in our institution between 2007 and 2013. The evaluation items were immune and nutritional indices, such as neutrophil/lym- phocyte ratio(NLR), platelet/lymphocyte ratio(PLR), lymphocyte/monocyte ratio(LMR), and the Onodera nutritional index (PNI). Moreover, we analyzed the relationship between immune and nutritional indices and outcome, overall survival(OS), and recurrence-free survival(RFS). Univariate and multivariate analyses showed that low LMR was significantly related to high mortality. Univariate analysis showed that high NLR, low LMR, and low PNIwere significantly related to a decrease in OS. Multivariate analysis showed that PNIwas an independent predictor of OS. LMR is suggested as a new predictor for postoperative complications. PNIis suggested as a new prognostic factor in pStageⅡand Ⅲcolorectal cancer.
我们研究了我院结直肠癌患者的免疫和营养指标与预后之间的关系。我们回顾性分析了2007年至2013年间在我院接受根治性手术的196例Ⅱ期和Ⅲ期结直肠癌患者。评估项目为免疫和营养指标，如中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、淋巴细胞/单核细胞比值（LMR）和小野寺营养指数（PNI）。此外，我们分析了免疫和营养指标与预后、总生存期（OS）和无复发生存期（RFS）之间的关系。单因素和多因素分析显示，低LMR与高死亡率显著相关。单因素分析显示，高NLR、低LMR和低PNI与OS降低显著相关。多因素分析显示，PNI是OS的独立预测因素。LMR被认为是术后并发症的新预测指标。PNI被认为是Ⅱ期和Ⅲ期结直肠癌的新预后因素。
