Division of Infectious Diseases, New York Medical College, Valhalla, New York, USA.
Clin Infect Dis. 2020 Nov 5;71(8):2014-2017. doi: 10.1093/cid/ciaa240.
Important human infections caused by spirochetal microorganisms include Lyme disease, syphilis, leptospirosis, and tick-borne relapsing fever. Doxycycline prophylactic regimens have been shown to significantly reduce the risk for developing all of these infections in potentially exposed individuals, which is highly clinically relevant as no vaccines to prevent these infections in humans are currently available. Additional data, however, are needed to define more precisely the level of efficacy of the doxycycline prophylactic regimens, especially for Lyme disease and syphilis, infections that can be potentially prevented by a single 200-mg dose of doxycycline given within 72 hours postexposure.
重要的由螺旋体微生物引起的人类感染包括莱姆病、梅毒、钩端螺旋体病和蜱传回归热。多西环素预防方案已被证明可显著降低潜在暴露个体发生所有这些感染的风险，这在临床上具有重要意义，因为目前尚无预防这些人类感染的疫苗。然而，需要更多的数据来更精确地确定多西环素预防方案的疗效水平，特别是对于莱姆病和梅毒，这两种感染可以通过在暴露后 72 小时内单次给予 200 毫克多西环素来预防。
