Division of Infectious Diseases, New York Medical College, Valhalla, NY, USA.
Department of Medicine, New York Medical College, Valhalla, NY, USA.
Diagn Microbiol Infect Dis. 2021 Apr;99(4):115293. doi: 10.1016/j.diagmicrobio.2020.115293. Epub 2020 Dec 13.
Single-dose doxycycline, given within 72 hours of exposure, has been evaluated in 4 clinical studies for postexposure prophylaxis of 3 spirochetal infections: Lyme disease, syphilis, and tick-borne relapsing fever. In this study, data from the 4 studies were aggregated using a meta-analytic random-effects approach, with the DerSimonian-Laird method for variance estimation, analyzing a total of 2468 subjects. The findings of this analysis demonstrated an overall efficacy rate for prevention of the 3 spirochetal infections of 78% (95% confidence interval: 50%-91%).
单剂多西环素，在暴露后 72 小时内使用，已在 4 项临床研究中评估了对 3 种螺旋体感染的暴露后预防作用：莱姆病、梅毒和蜱传回归热。在这项研究中，使用荟萃分析随机效应方法汇总了 4 项研究的数据，方差估计采用 DerSimonian-Laird 方法，共分析了 2468 名受试者。该分析的结果表明，3 种螺旋体感染的总体预防有效率为 78%（95%置信区间：50%-91%）。
