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病例报告:眼微孢子虫病:一位从印度返回的患者的病例及文献复习。

Case Report: Ocular Microsporidiosis: Case in a Patient Returning from India and Review of the Literature.

机构信息

Institut National de la Santé et de la Recherche Médicale, Unité 995-Lille Inflammation Research International Center, Fungal Associated Invasive & Inflammatory Diseases, Lille, France.

Service de Parasitologie-Mycologie, Lille University Hospital, Lille, France.

出版信息

Am J Trop Med Hyg. 2018 Jul;99(1):90-93. doi: 10.4269/ajtmh.18-0015. Epub 2018 Apr 19.

Abstract

Microsporidia are protists close to the kingdom of fungi that may cause eye infections. Most cases are reported in Asia and affect both immunocompromised and immunocompetent patients. Here, we report a rare case of microsporidial keratoconjunctivitis in an immunocompetent French patient 3 weeks after returning from India. In our patient, Weber trichrome staining of conjunctival scrapings revealed rounded elements approximately 1-3 μm in size. Conventional polymerase chain reaction analysis by ribosomal RNA subunit sequencing showed 100% identity with . Treatment by corneal debridement combined with fluoroquinolone eye drops allowed complete resolution of the lesions. Although rare, ocular microsporidiosis should be investigated in a patient who is native to Asia or has returned from an endemic area and presents with keratoconjunctivitis of undetermined etiology.

摘要

微孢子虫是与真菌王国关系密切的原生动物,可能引起眼部感染。大多数病例报告发生在亚洲,影响免疫功能低下和免疫功能正常的患者。在这里,我们报告了一例罕见的免疫功能正常的法国患者在从印度返回后 3 周发生的微孢子虫性角膜炎。在我们的患者中,韦伯三色染色结膜刮片显示出约 1-3μm 大小的圆形元素。核糖体 RNA 亚单位测序的常规聚合酶链反应分析显示与 100%一致。角膜清创术联合氟喹诺酮滴眼剂治疗可使病变完全消退。尽管罕见,但对于来自亚洲或从流行地区返回且出现病因不明的角结膜炎的患者,应检查眼部微孢子虫病。

相似文献

3
Deep microsporidial keratitis after keratoconjunctivitis.角结膜炎后深部微孢子虫性角膜炎
Clin Exp Ophthalmol. 2011 Aug;39(6):577-80. doi: 10.1111/j.1442-9071.2011.02505.x.

本文引用的文献

4
Microsporidia - Emergent Pathogens in the Global Food Chain.微孢子虫——全球食物链中的新兴病原体。
Trends Parasitol. 2016 Apr;32(4):336-348. doi: 10.1016/j.pt.2015.12.004. Epub 2016 Jan 19.

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