Department of Ophthalmology, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Mimar Sinan Mah Emniyet Cad Polis Okulu Karşısı, Yıldırım, 16310, Bursa, Turkey.
Department of Ophthalmology, Bursa City Hospital, Bursa, Turkey.
Acta Neurol Belg. 2021 Dec;121(6):1449-1455. doi: 10.1007/s13760-020-01325-2. Epub 2020 Mar 10.
To compare the foveal avascular zone (FAZ), macular and peripapillary vessel density and retinal nerve fiber layer (RNFL) thickness between pediatric migraine patients and healthy subjects. A total of 108 eyes of 54 children with migraine without aura and 94 eyes of 47 age- and gender-matched healthy subjects were included. Capillary vessel density (CVD) in superficial (SCP) and deep (DCP) retinal capillary plexus, peripapillary region, FAZ, and RNFL thickness were analyzed by optical coherence tomography-angiography. The mean ages were 12.4 ± 3.3 years (range 6-18) in patients with migraine and 12.6 ± 2.9 years (range 5-18) in healthy controls (p = 0.742). The mean FAZ area measured 0.27 ± 0.09 mm in the pediatric migraineurs and 0.26 ± 0.09 mm in healthy controls (p = 0.53). There was no significant difference in any measurement of SCP, DCP, peripapillary CVD, and RNFL thickness between study groups (p > 0.05 for all). The pediatric migraine disability assessment test (PedMIDAS) negatively correlated with some of the CVD and RNFL measurements in pediatric migraine patients (p < 0.05). The macular and peripapillary microvasculature were not significantly different during an attack-free period in pediatric migraine patients than in healthy subjects.
比较儿科偏头痛患者和健康受试者之间的中心凹无血管区（FAZ）、黄斑和视盘周围血管密度以及视网膜神经纤维层（RNFL）厚度。共纳入 54 例无先兆偏头痛儿童的 108 只眼和 47 例年龄和性别匹配的健康对照者的 94 只眼。通过光学相干断层扫描血管造影分析浅层（SCP）和深层（DCP）视网膜毛细血管丛、视盘周围区域、FAZ 和 RNFL 厚度的毛细血管血管密度（CVD）。偏头痛患者的平均年龄为 12.4 ± 3.3 岁（范围 6-18 岁），健康对照组为 12.6 ± 2.9 岁（范围 5-18 岁）（p = 0.742）。儿科偏头痛患者的平均 FAZ 面积为 0.27 ± 0.09mm，健康对照组为 0.26 ± 0.09mm（p = 0.53）。两组间 SCP、DCP、视盘周围 CVD 和 RNFL 厚度的任何测量均无显著差异（p > 0.05）。儿科偏头痛残疾评估测试（PedMIDAS）与儿科偏头痛患者的一些 CVD 和 RNFL 测量值呈负相关（p < 0.05）。在无偏头痛发作期间，儿科偏头痛患者的黄斑和视盘周围微血管结构与健康受试者无显著差异。
