Department of Ophthalmology, Habib Bourguiba Hospital, 3029 Sfax, Tunisia.
Department of Neurology, Habib Bourguiba Hospital, 3029 Sfax, Tunisia.
J Clin Neurosci. 2024 Aug;126:348-352. doi: 10.1016/j.jocn.2024.07.010. Epub 2024 Jul 19.
Migraine, classified as a neurovascular disease, has been identified as a potential risk factor for ocular vascular complications. Our study aimed to compare retinal vessel density and perfusion density between subjects with migraine and healthy subjects using optical coherence tomography angiography (OCTA). In this cross-sectional case-control study, we enrolled 30 migraine subjects with aura (MWA), 30 migraine subjects without aura (MWOA) and 30 age and gender-matched healthy controls (HC). The foveal avascular zone (FAZ) in superficial capillary plexus (SCP), Vessel density (VD) and perfusion density (PD) in SCP and deep capillary plexus (DCP) were assessed in a 3 × 3 mm scan of the macula with the swept source OCT. Results indicated that the FAZ of MWA and MWOA subjects was significantly larger from HC. Also, FAZ of MWA was larger from MWOA. VD and PD in both SCP and DCP were significantly reduced in both MWA and MWOA groups compared to HC. However, VD and PD did not show significant differences among MWA and MWOA. Additionally, the duration of disease was the main determinant of the FAZ. In conclusion, the FAZ in the SCP, VD and PD in the SCP and DCP of the macula were affected in both MWA and MWOA. FAZ, specifically, was increased with the evolution of the disease. These findings might contribute to an increased risk of ocular vascular complications among subjects with migraine and could potentially use OCTA as a biomarker for this population.
偏头痛被归类为一种神经血管疾病，已被确定为眼部血管并发症的潜在危险因素。我们的研究旨在使用光相干断层扫描血管造影术（OCTA）比较偏头痛患者和健康受试者的视网膜血管密度和灌注密度。在这项横断面病例对照研究中，我们纳入了 30 名有先兆偏头痛患者（MWA）、30 名无先兆偏头痛患者（MWOA）和 30 名年龄和性别匹配的健康对照者（HC）。使用扫频源 OCT 对黄斑区 3×3mm 扫描，评估浅层毛细血管丛（SCP）中的中心凹无血管区（FAZ）、SCP 和深层毛细血管丛（DCP）中的血管密度（VD）和灌注密度（PD）。结果表明，MWA 和 MWOA 受试者的 FAZ 明显大于 HC。此外，MWA 的 FAZ 大于 MWOA。与 HC 相比，MWA 和 MWOA 组的 SCP 和 DCP 中的 VD 和 PD 均显著降低。然而，MWA 和 MWOA 之间的 VD 和 PD 没有显著差异。此外，疾病持续时间是 FAZ 的主要决定因素。总之，MWA 和 MWOA 患者的 SCP 中的 FAZ、SCP 和 DCP 中的 VD 和 PD 均受到影响。特别是 FAZ 随着疾病的发展而增加。这些发现可能会增加偏头痛患者发生眼部血管并发症的风险，并可能使用 OCTA 作为该人群的生物标志物。
