Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Cancer Invest. 2020 Apr;38(4):214-227. doi: 10.1080/07357907.2020.1741604. Epub 2020 Mar 19.
Cripto-1 is a plasma membrane protein which is not expressed in adult tissue, but some tumors are accompanied by re-activation. We studied the clinical and biological significance of Cripto-1 in colorectal cancer. Cripto-1 was positive in 68 out of 192 cases (35%) by immunohistochemistry. Cripto-1 expression was correlated with worse prognosis and was an independent prognostic factor. Cripto-1-silenced colorectal cancer cell lines had reduced cell proliferation, migration, and activation of Akt and MAPK signaling pathways , and decreased tumor growth and lymph node metastasis . Cripto-1 could be a useful prognostic biomarker and therapeutic target in colorectal cancer.
Cripto-1 是一种质膜蛋白，在成人组织中不表达，但一些肿瘤伴有重新激活。我们研究了 Cripto-1 在结直肠癌中的临床和生物学意义。免疫组织化学显示，192 例中有 68 例（35%）呈阳性。Cripto-1 的表达与预后不良相关，是独立的预后因素。沉默 Cripto-1 的结直肠癌细胞系的细胞增殖、迁移以及 Akt 和 MAPK 信号通路的活性降低，肿瘤生长和淋巴结转移减少。Cripto-1 可能是结直肠癌有价值的预后生物标志物和治疗靶点。
