Ohta Nobuo, Waki Takayoshi, Ito Tsukasa, Suzuki Yusuke, Kakehata Seiji, Aoyagi Masaru
Division of Otolaryngology, Tohoku Medical and Pharmaceutical University, Sendai 981-0905, Japan.
Department of Otolaryngology, Head and Neck Surgery, Yamagata University, Yamagata 990-1122.
Yonago Acta Med. 2020 Feb 20;63(1):88-91. doi: 10.33160/yam.2020.02.010. eCollection 2020 Feb.
We present the case of a 58-year-old Japanese woman with a natural killer T (NK/T)-cell lymphoma complicated by brain abscess. NK/T-cell lymphomas represent a rare type of lymphoma derived from either activated NK cells or, rarely, cytotoxic T cells. They are aggressive Epstein-Barr virus (EBV)-associated lymphomas that involve mainly the nasal cavity. Brain abscess associated with primary extranodal nasal-type NK/T-cell lymphoma is extremely uncommon: to our knowledge, this is the first reported case of this lymphoma with brain abscess as the initial clinical manifestation. Endoscopic surgery was performed for definitive diagnosis under intraoperative navigation system. Chemotherapy followed by radiotherapy was performed and was effective: 72 months later the tumor has not recurred. Recommendations of endoscopic management for diagnosis and treatment of this rare neoplasm are discussed.
我们报告了一例58岁的日本女性，患有自然杀伤T（NK/T）细胞淋巴瘤并伴有脑脓肿。NK/T细胞淋巴瘤是一种罕见的淋巴瘤，起源于活化的NK细胞，或极少情况下起源于细胞毒性T细胞。它们是侵袭性的与EB病毒（EBV）相关的淋巴瘤，主要累及鼻腔。与原发性结外鼻型NK/T细胞淋巴瘤相关的脑脓肿极为罕见：据我们所知，这是首例以脑脓肿为首发临床表现的该型淋巴瘤病例。在术中导航系统辅助下进行了内镜手术以明确诊断。术后进行了化疗及放疗，效果良好：72个月后肿瘤未复发。本文还讨论了针对这种罕见肿瘤的内镜诊断和治疗建议。
