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南非夸祖鲁-纳塔尔省一家儿科和青少年艾滋病毒诊所实施健康周年纪念活动后,艾滋病毒载量检测的覆盖率和及时性

HIV viral load testing coverage and timeliness after implementation of the wellness anniversary in a paediatric and adolescent HIV clinic in KwaZulu-Natal, South Africa.

作者信息

Kubheka Sibusiso E, Archary Moherndran, Naidu Kevindra K

机构信息

Department of Paediatrics and Child Health, College of Health Sciences, School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.

Maternal, Child and Adolescent Health, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

出版信息

South Afr J HIV Med. 2020 Feb 3;21(1):1016. doi: 10.4102/sajhivmed.v21i1.1016. eCollection 2020.

Abstract

BACKGROUND

The UNAIDS 2020 Global strategy to reduce the transmission of HIV includes ensuring HIV viral load (VL) testing coverage of at least 90% on all patients on antiretroviral therapy (ART). Routine VL monitoring has been shown to result in earlier detection of treatment failure, timely regimen switches, promotion of adherence to treatment and improved survival. We wanted to assess the introduction of the wellness anniversary in improving routine viral load monitoring.

OBJECTIVES

We retrospectively assessed effects of the wellness anniversary on routine VL coverage, timeliness and suppression rates.

METHOD

The month when the patient initiated ART was designated as the wellness anniversary. On the anniversary month a package of care, which included a routine VL, was delivered. We conducted a retrospective chart audit to assess VL coverage and timeliness between two time periods, from January 2016 to December 2016 (pre-implementation) and from January 2017 to December 2017 (post-implementation).

RESULTS

Timeliness of VL testing improved from 27.5% in the pre-implementation cohort to 49.7% in the post-implementation cohort. Our study showed high VL testing coverage before the implementation of the wellness anniversary with an average of 98.3% VL. There was a significant correlation between timeliness and VL suppression (VLS) in the post-implementation group.

CONCLUSION

Implementation of the wellness anniversary may improve timeliness of routine VL testing in settings with high VL coverage. Studies looking at the effect of timeliness on VLS and clinical outcomes are needed.

摘要

背景

联合国艾滋病规划署(UNAIDS)2020年减少艾滋病毒传播的全球战略包括确保接受抗逆转录病毒治疗(ART)的所有患者的艾滋病毒病毒载量(VL)检测覆盖率至少达到90%。常规病毒载量监测已被证明能更早地发现治疗失败,及时更换治疗方案,促进治疗依从性并提高生存率。我们希望评估引入健康周年纪念活动对改善常规病毒载量监测的作用。

目的

我们回顾性评估了健康周年纪念活动对常规病毒载量覆盖率、及时性和抑制率的影响。

方法

将患者开始接受抗逆转录病毒治疗的月份指定为健康周年纪念月。在周年纪念月提供一套护理服务,其中包括一次常规病毒载量检测。我们进行了一项回顾性病历审查,以评估2016年1月至2016年12月(实施前)和2017年1月至2017年12月(实施后)这两个时间段之间的病毒载量覆盖率和及时性。

结果

病毒载量检测的及时性从实施前队列中的27.5%提高到实施后队列中的49.7%。我们的研究显示,在实施健康周年纪念活动之前,病毒载量检测覆盖率很高,平均为98.3%。在实施后组中,及时性与病毒载量抑制(VLS)之间存在显著相关性。

结论

在病毒载量覆盖率高的环境中,实施健康周年纪念活动可能会提高常规病毒载量检测的及时性。需要开展研究以探讨及时性对病毒载量抑制和临床结局的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/776b/7059249/3ed66d15ff62/HIVMED-21-1016-g001.jpg

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