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瞄准第三个“90”:介绍病毒载量冠军。

Targeting the third '90': introducing the viral load champion.

作者信息

Sunpath H, Hatlen T J, Naidu K K, Msimango P, Adams R N, Moosa M-Y S, Marconi V C, Murphy R A, Gandhi R T, Pillay S, Siedner M, Naidoo K

机构信息

Centre for Aids Program of Research, University of Kwa Zulu-Natal, Durban, South Africa.

Infectious Diseases Unit, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

出版信息

Public Health Action. 2018 Dec 21;8(4):225-231. doi: 10.5588/pha.18.0063.

Abstract

To move closer to achieving the third target of the UNAIDS 90-90-90 goals, we prospectively implemented a viral load (VL) champion (VLC) program aimed at enhancing VL monitoring and recognition of treatment failure. Three clinics in eThekwini, Kwa-Zulu Natal (low-, medium- and high-volume, encompassing 9184 patients overall) were each assigned a VLC. We employed a descriptive analysis (chart audit) to compare the pre-intervention period to a 1-year post-intervention period. The number of patients with a VL test performed 6 and 12 months after the intervention was calculated as a proportion of VL tests due at those time points (VL completion rate). The pre-implementation VL completion rate at the three sites was respectively 68% (140/205 patients), 54% (84/155 patients) and 64% (323/504 patients), and the 6-month post-implementation completion rate increased to 83% (995/1194 patients), 90% (793/878 patients) and 99% (3101/3124 patients) ( < 0.0001 for each site). VL completion rates remained significantly higher at 12 months post-implementation, with an average cumulative VL completion rate of >90% across all facilities. We demonstrate a successful, multifaceted, quality-improvement intervention centered on a clinic-level VLC which, taken to scale, has important implications for attaining the third UNAIDS 90-90-90 target.

摘要

为了更接近实现联合国艾滋病规划署90-90-90目标的第三个指标,我们前瞻性地实施了一项病毒载量(VL)倡导者(VLC)计划,旨在加强VL监测和对治疗失败的识别。夸祖鲁-纳塔尔省伊泰夸尼的三家诊所(低、中、高就诊量,总共涵盖9184名患者)各分配了一名VLC。我们采用描述性分析(图表审核)将干预前期与干预后1年进行比较。计算干预后6个月和12个月进行VL检测的患者数量占当时应进行VL检测的比例(VL完成率)。三个地点实施前的VL完成率分别为68%(140/205名患者)、54%(84/155名患者)和64%(323/504名患者),实施后6个月的完成率分别提高到83%(995/1194名患者)、90%(793/878名患者)和99%(3101/3124名患者)(每个地点P<0.0001)。实施后12个月时VL完成率仍显著更高,所有机构的平均累积VL完成率>90%。我们展示了一项以诊所层面的VLC为核心的成功、多方面的质量改进干预措施,若推广开来,对实现联合国艾滋病规划署90-90-90的第三个目标具有重要意义。

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