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大细胞神经内分泌癌和小细胞肺癌的新模型。

New models of large-cell neuroendocrine carcinoma and small-cell lung carcinoma.

作者信息

Santos Mirentxu

机构信息

Basic Research Department, Molecular Oncology Unit, Madrid, Spain.

Basic Research Department, CIBERONC, Centro de Investigación Biomédica en Red de Cáncer, Spain.

出版信息

Mol Cell Oncol. 2020 Jan 7;7(2):1702413. doi: 10.1080/23723556.2019.1702413. eCollection 2020.

DOI:10.1080/23723556.2019.1702413
PMID:32158917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7051149/
Abstract

High-grade neuroendocrine lung carcinomas (LCNEC, SCLC) are recalcitrant cancers for which no optimal management has been achieved. We have recently described two models of LCNEC and SCLC developed upon inactivation of 4 tumor suppressors genes ( (RB transcriptional corepressor 1), (RB transcriptional corepressor like 1), (phosphatase and tensin homolog), (transformation-related protein 53), which provide a suitable frame for preclinical intervention. A defined model for LCNEC had not been previously reported.

摘要

高级别神经内分泌肺癌（大细胞神经内分泌癌、小细胞肺癌）是难治性癌症，尚未实现最佳治疗方案。我们最近描述了两种基于4种肿瘤抑制基因（视网膜母细胞瘤转录共抑制因子1、视网膜母细胞瘤转录共抑制因子样1、磷酸酶和张力蛋白同源物、肿瘤蛋白p53）失活而建立的大细胞神经内分泌癌和小细胞肺癌模型，这些模型为临床前干预提供了合适的框架。此前尚未报道过明确的大细胞神经内分泌癌模型。

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Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22300-22306. doi: 10.1073/pnas.1821745116. Epub 2019 Oct 14.
2
Deciphering the cells of origin of squamous cell carcinomas.解析鳞状细胞癌的起源细胞。
Nat Rev Cancer. 2018 Sep;18(9):549-561. doi: 10.1038/s41568-018-0024-5.
3
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.大细胞神经内分泌癌的综合基因组分析揭示了高级别神经内分泌肺肿瘤的不同亚型。
Nat Commun. 2018 Mar 13;9(1):1048. doi: 10.1038/s41467-018-03099-x.
4
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.2015 年世界卫生组织肺肿瘤分类：自 2004 年分类以来遗传、临床和放射学进展的影响。
J Thorac Oncol. 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630.
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Origins, genetic landscape, and emerging therapies of small cell lung cancer.小细胞肺癌的起源、基因图谱及新兴疗法
Genes Dev. 2015 Jul 15;29(14):1447-62. doi: 10.1101/gad.263145.115.
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