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组蛋白去乙酰化酶有助于断裂叉的精确修复。

Histone deacetylases facilitate the accurate repair of broken forks.

作者信息

Gómez-González Belén, Ortega Pedro, Aguilera Andrés

机构信息

Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.

出版信息

Mol Cell Oncol. 2020 Jan 13;7(2):1705731. doi: 10.1080/23723556.2019.1705731. eCollection 2020.

DOI:10.1080/23723556.2019.1705731
PMID:32158920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7051162/
Abstract

We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and enhancing genetic instability. Here we discuss the possible implications of our findings given that histone deacetylases are a promising chemotherapeutic target often used in combination with DNA damaging agents.

摘要

我们最近发现，酵母组蛋白去乙酰化酶Rpd3（降低钾依赖性3）和Hda1（组蛋白去乙酰化酶3）的缺失会影响姐妹染色单体之间的黏连，从而损害复制叉处DNA损伤的修复并增强遗传不稳定性。鉴于组蛋白去乙酰化酶是一种常用作与DNA损伤剂联合使用的很有前景的化疗靶点，在此我们讨论我们研究结果的可能影响。

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Nat Commun. 2019 Nov 15;10(1):5178. doi: 10.1038/s41467-019-13210-5.
2
Rpd3L Contributes to the DNA Damage Sensitivity of Checkpoint Mutants.Rpd3L 有助于检查点突变体的 DNA 损伤敏感性。
Genetics. 2019 Feb;211(2):503-513. doi: 10.1534/genetics.118.301817. Epub 2018 Dec 17.
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Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi.组蛋白去乙酰化酶抑制剂（HDACi）联合疗法治疗癌症：实现HDACi的全部治疗潜力
Front Oncol. 2018 Mar 29;8:92. doi: 10.3389/fonc.2018.00092. eCollection 2018.
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Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.组蛋白去乙酰化酶抑制剂诱导 DNA 损伤，正常细胞而非转化细胞可以修复这种损伤。
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