Vaghela Jitendra H, Shah Jigna H, Patel Jaladhi H, Purohit Bhargav M
Department of Pharmacology, NAMO Medical College & Research Institute, Silvassa, Dadra and Nagar Haveli, India.
Department of Dentistry, Sir Takhtasinhji General Hospital & Government Medical College, Bhavnagar, Gujarat, India.
J Dent Anesth Pain Med. 2020 Feb;20(1):19-27. doi: 10.17245/jdapm.2020.20.1.19. Epub 2020 Feb 28.
Surgical extraction of third molars is associated with postoperative pain and swelling at the extraction site. Pain is commonly managed using non-steroidal anti-inflammatory drugs (NSAIDs). Postoperative pain is usually moderate to severe in the first 12 h postoperatively and lasts for 3-5 days. However, with NSAIDs, these symptoms usually subside within 24 h. Diclofenac sodium and etodolac are NSAIDs, more selectively cyclooxygenase-2 inhibitors, with good analgesic efficacies.
We compared the safety and analgesic efficacy of diclofenac sodium with etodolac peroral after surgical extraction of third molars in a double-blind, double-dummy, parallel-group study. The subjective pain improvement and pain relief after 2, 6, 24, 48, and 72 h using the visual analogue scale were measured as the study outcome.
Etodolac was equivalent to diclofenac sodium in pain alleviation at all postoperative time periods. No significant differences were found between diclofenac sodium and etodolac groups (P > 0.05). Both study medications were well tolerated and safe with mild adverse effects in only a few participants.
Diclofenac sodium and etodolac are comparable in terms of analgesic efficacy and safety after surgical removal of third molars.
第三磨牙的外科拔除与拔牙部位术后疼痛和肿胀有关。疼痛通常使用非甾体抗炎药（NSAIDs）进行处理。术后疼痛在术后最初12小时通常为中度至重度，并持续3 - 5天。然而，使用NSAIDs后，这些症状通常在24小时内消退。双氯芬酸钠和依托度酸属于NSAIDs，更具选择性的环氧化酶-2抑制剂，具有良好的镇痛效果。
在一项双盲、双模拟、平行组研究中，我们比较了双氯芬酸钠与依托度酸口服给药在第三磨牙外科拔除术后的安全性和镇痛效果。使用视觉模拟量表测量术后2、6、24、48和72小时主观疼痛改善情况及疼痛缓解程度作为研究结果。
在所有术后时间段，依托度酸在缓解疼痛方面与双氯芬酸钠相当。双氯芬酸钠组和依托度酸组之间未发现显著差异（P>0.05）。两种研究药物耐受性良好且安全，仅少数参与者有轻微不良反应。
在第三磨牙拔除术后，双氯芬酸钠和依托度酸在镇痛效果和安全性方面具有可比性。
