Molecular and Structural Biophysics Laboratory, Department of Biochemistry, North-Eastern Hill University, Umshing, Shillong 793022, Meghalaya, India.
ACS Infect Dis. 2020 May 8;6(5):893-895. doi: 10.1021/acsinfecdis.0c00072. Epub 2020 Mar 11.
Species of the blood fluke are responsible for schistosomiasis, the second most common parasitic disease, which is prevalent particularly in poor communities. Under redox pressure, schistosomes survive in mammalian hosts with the help of thioredoxin glutathione reductase, which is an essential selenoenzyme. A recent study identified compounds with extremely potent antischistosome activity. Most importantly, certain compounds were active against all major schistosomes across different life cycle stages, where even praziquantel, the drug of choice, fails. The data offer compounds that exceed WHO standards for leads for schistosomiasis therapy activity. The work may serve as the basis for the development of new antischistosome compounds.
血吸虫物种是血吸虫病的罪魁祸首，这是第二大常见寄生虫病，尤其在贫困社区流行。在氧化还原压力下，血吸虫在哺乳动物宿主中生存，这要归功于硫氧还蛋白-谷胱甘肽还原酶，这是一种必需的硒酶。最近的一项研究发现了具有极强抗血吸虫活性的化合物。最重要的是，某些化合物对所有主要血吸虫都具有活性，而不同生命周期阶段的药物吡喹酮都无法做到这一点。这些数据提供了超过世界卫生组织标准的抗血吸虫病治疗活性的先导化合物。这项工作可以为开发新的抗血吸虫化合物奠定基础。
