使用氘代内标物对生物流体中白消安进行气相色谱-质谱分析。 - Suppr

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超能文献

Gas chromatographic-mass spectrometric assay for busulfan in biological fluids using a deuterated internal standard.

作者信息

Vassal G, Re M, Gouyette A

机构信息

Clinical Pharmacology Unit (UA147 CNRS, U140 INSERM), Institut Gustave-Roussy, Villejuif, France.

出版信息

J Chromatogr. 1988 Jul 15;428(2):357-61. doi: 10.1016/s0378-4347(00)83928-6.

DOI:10.1016/s0378-4347(00)83928-6

PMID:3215938

Abstract

摘要

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Gas chromatographic-mass spectrometric assay for busulfan in biological fluids using a deuterated internal standard.使用氘代内标物对生物流体中白消安进行气相色谱-质谱分析。

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Quantification of urinary 3-hydroxyisovaleric acid using deuterated 3-hydroxyisovaleric acid as internal standard.以氘代3-羟基异戊酸为内标物对尿中3-羟基异戊酸进行定量分析。

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Exposure equivalence between IV (0.8 mg/kg) and oral (1 mg/kg) busulfan in adult patients.成年患者中静脉注射（0.8毫克/千克）与口服（1毫克/千克）白消安的暴露等效性。

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The role of busulfan in bone marrow transplantation.白消安在骨髓移植中的作用。

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Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations.白消安在无胸腺小鼠中，以临床可达到的血浆药物浓度对神经母细胞瘤和髓母细胞瘤异种移植瘤具有活性。

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