Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy.
School of Molecular Sciences, University of Western Australia, Perth, Australia.
Nat Prod Res. 2021 Nov;35(22):4508-4516. doi: 10.1080/14786419.2020.1737058. Epub 2020 Mar 11.
Endophytic fungi have several well-established beneficial effects on plant health and growth, and are a huge source of bioactive compounds. The endophyte sp. strain 678, isolated from the roots of an Australian native grass , demonstrated efficacy against four plant pathogens (, , , ). In addition, strain 678 was capable of degrading a common additive used in gasoline, known as methyl tertiary-butyl ether (MtBE). Thus, the organic extracts obtained from the culture filtrate of strain 678 were studied. Metabolomic analysis revealed the presence of two major bioactive metabolites, monocerin and an alkynyl substituted epoxycyclohexenone derivative, which showed good antifungal activity. The sp. strain 678 and its compounds show promise for applications in biocontrol and bioremediation activities in agriculture or as a remediation option for MtBE contamination in soil.
内生真菌对植物的健康和生长有几种已被证实的有益作用，并且是生物活性化合物的巨大来源。从澳大利亚本地草的根部分离出的内生真菌 sp. 菌株 678 对四种植物病原体（、、、）具有疗效。此外，菌株 678 能够降解一种常见的汽油添加剂，称为甲基叔丁基醚（MtBE）。因此，研究了从菌株 678 的培养液滤液中获得的有机提取物。代谢组学分析显示存在两种主要的生物活性代谢物，即单端孢菌素和炔基取代的环氧环己烯酮衍生物，它们表现出良好的抗真菌活性。内生真菌 sp. 菌株 678 及其化合物有望在农业中的生物防治和生物修复活动中得到应用，或者作为土壤中 MtBE 污染的修复选择。
