Sena Berilany Dos Santos, Andrade Maria Izabel Siqueira de, Silva Ana Paula Ferreira da, Dourado Keila Fernandes, Silva Andressa Laís Ferreira
Universidade Federal de Pernambuco, Vitória de Santo Antão, PE, Brazil.
Hospital Barão de Lucena, Recife, PE, Brazil.
Rev Paul Pediatr. 2020 Mar 9;38:e2018201. doi: 10.1590/1984-0462/2020/38/2018201. eCollection 2020.
To verify the occurrence of overweight in children and adolescents with phenylketonuria and to identify possible causal factors.
A systematic review was performed in the SciELO, PubMed and VHL databases using the descriptors "Phenylketonurias", "Overweight", "Child" and "Adolescent". Original articles conducted with children and adolescents, published between 2008 and 2018 in Portuguese, English or Spanish languages were included.
A total of 16 articles were identified and, after screening procedures, 6 studies were selected for the review. Overweight in children and adolescents with phenylketonuria was a frequent occurence in the studies included in this review, ranging from 7.8 to 32.6%. The female sex was the most affected by the nutritional disorder. Furthermore, a high caloric intake combined with a lack of stimuli to practice physical activities were main factors associated with the excessive weight in the population of interest.
Excess weight can be considered a common outcome in children and adolescents with phenylketonuria. It is mainly caused by inadequate food consumption and sedentary lifestyle. The importance of early identification of nutritional disturbances in children and adolescents with phenylketonuria should be emphasized, in order to prevent associated chronic diseases and to promote health by encouraging continued healthy eating habits and the regular practice of physical exercises.
验证苯丙酮尿症儿童和青少年超重情况的发生，并确定可能的因果因素。
在SciELO、PubMed和VHL数据库中进行了系统综述，使用了“苯丙酮尿症”“超重”“儿童”和“青少年”等描述词。纳入2008年至2018年期间以葡萄牙语、英语或西班牙语发表的针对儿童和青少年的原创文章。
共识别出16篇文章，经过筛选程序，选择了6项研究进行综述。本综述纳入的研究中，苯丙酮尿症儿童和青少年超重情况较为常见，发生率在7.8%至32.6%之间。女性受这种营养紊乱的影响最大。此外，高热量摄入加上缺乏体育活动刺激是与该人群超重相关的主要因素。
超重可被视为苯丙酮尿症儿童和青少年的常见结果。其主要由食物摄入不足和久坐不动的生活方式引起。应强调早期识别苯丙酮尿症儿童和青少年营养紊乱的重要性，以预防相关慢性病，并通过鼓励持续的健康饮食习惯和定期体育锻炼来促进健康。
