Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Pediatria, Belo Horizonte, MG, Brazil; Programa de Pós-Graduação em Ciências da Saúde - Saúde da Criança e do Adolescente, Ciências da Saúde, Belo Horizonte, MG, Brazil; Faculdade de Minas (FAMINAS-BH), Departamento de Nutrição, Belo Horizonte, MG, Brazil.
Faculdade de Minas (FAMINAS-BH), Departamento de Nutrição, Belo Horizonte, MG, Brazil.
J Pediatr (Rio J). 2022 Jan-Feb;98(1):104-110. doi: 10.1016/j.jped.2021.04.009. Epub 2021 Jun 16.
To estimate the prevalence and factors associated with overweight/obesity development in adolescents with early diagnosed phenylketonuria treated exclusively by diet.
In this cross-sectional study anthropometric measurements, serum phenylalanine levels, and 10 metabolites associated with lipid and carbohydrate metabolism were analyzed in 101 adolescents aged 10-20 years. Adolescents were categorized into overweight/obesity and eutrophic/low body mass index groups. These patients were compared using Student's t-test, Pearson's chi-square test, Wald's chi-square test for multivariate analysis. Further, to verify whether the prevalence of overweight/obesity found in the study population was similar to that in the general population, the authors compared the nutritional status of 46 patients aged 13-17 years with that of healthy students of the same age from the National School Health Survey using the chi-square test for adherence. The significance threshold was p < 0.5.
The prevalence of overweight/obesity in adolescents was 27.7%. There was no difference in prevalence between sexes. Older age was a protective factor and Increased Homeostasis Model Assessment Insulin Resistance index and high phenylalanine and low-density lipoprotein cholesterol levels were predictive factors for overweight/obesity. The equality hypothesis was not rejected in the comparison of nutritional states of 46 patients aged 13-17 years and healthy students of the same age.
The prevalence of overweight/obesity in phenylketonuria adolescents was similar to what is found in healthy adolescents.
评估单纯饮食治疗的早发型苯丙酮尿症青少年超重/肥胖发展的患病率及相关因素。
在这项横断面研究中，分析了 101 名 10-20 岁青少年的人体测量学指标、血清苯丙氨酸水平以及与脂代谢和碳水化合物代谢相关的 10 种代谢物。将青少年分为超重/肥胖组和营养良好/低体重指数组。使用学生 t 检验、Pearson 卡方检验、Wald 卡方检验对多变量分析进行比较。此外，为了验证研究人群中超重/肥胖的患病率是否与普通人群相似，作者使用卡方检验对依从性进行了比较，比较了 46 名 13-17 岁患者和同年龄的全国学校健康调查中健康学生的营养状况。显著性阈值为 p<0.5。
青少年超重/肥胖的患病率为 27.7%。男女患病率无差异。年龄较大是保护因素，而稳态模型评估胰岛素抵抗指数增加、苯丙氨酸升高和低密度脂蛋白胆固醇降低是超重/肥胖的预测因素。在比较 46 名 13-17 岁患者和同年龄健康学生的营养状况时，平等假设没有被拒绝。
苯丙酮尿症青少年超重/肥胖的患病率与健康青少年相似。
