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评估银屑病关节炎的多面性:银屑病关节炎临床试验中的单一和复合指标。

Assessment of the many faces of PsA: single and composite measures in PsA clinical trials.

机构信息

Medical School, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.

出版信息

Rheumatology (Oxford). 2020 Mar 1;59(Suppl 1):i29-i36. doi: 10.1093/rheumatology/kez305.

Abstract

PsA is a complex, heterogeneous disease that can place a large burden on patients' psychological and physical well-being. The multifaceted nature of PsA poses a significant assessment challenge, both in randomized control trials and in clinical practice. In recent years, there has been much progress in the development of unidimensional and composite measures of disease activity, as well as of questionnaires that capture the patient's perspective of the condition. Despite these advances, there remains uncertainty around which tools to implement within a research setting. This review aims to summarize the currently available clinical and patient-derived assessment tools, providing a practical and informative resource for the assessment of PsA. This review will also explore recent advancements in digital approaches to the assessment of rheumatological conditions. This will highlight the potential for digitalization in the assessment and monitoring of PsA, outlining innovative means of capturing disease activity and treatment response.

摘要

PsA 是一种复杂的、异质性的疾病,会给患者的身心健康带来很大的负担。PsA 的多方面性质在随机对照试验和临床实践中都对评估提出了重大挑战。近年来,在疾病活动的单一和综合衡量指标以及捕捉患者对病情看法的问卷方面已经取得了很大进展。尽管取得了这些进展,但在研究环境中实施哪些工具仍存在不确定性。本综述旨在总结目前可用的临床和患者衍生的评估工具,为 PsA 的评估提供实用且有信息的资源。本综述还将探讨风湿病评估的数字化方法的最新进展。这将突出数字化在 PsA 的评估和监测中的潜力,提出捕捉疾病活动和治疗反应的创新方法。

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