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干细胞的形态和在消化系统手术中的应用。

The morphology and application of stem cells in digestive system surgery.

机构信息

Department of Anatomy, Medical University of Lublin, Poland.

Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Poland.

出版信息

Folia Morphol (Warsz). 2021;80(1):13-19. doi: 10.5603/FM.a2020.0024. Epub 2020 Mar 11.

DOI:10.5603/FM.a2020.0024
PMID:32159846
Abstract

BACKGROUND

Stem cells constitute a group of cells which possess the ability to self-renew as well as the capacity to differentiate into a vast number of different cells within the human organism. Moreover, stem cells are able to undergo a potentially unlimited number of divisions and this characteristic is clinically essential. Specific fields of its application include treatment of diseases mainly in the field of haematology, orthopaedics, surgery, dentistry, and neurology.

MATERIALS AND METHODS

In the following work, the current knowledge concerning mechanisms of stem cell treatment in different parts of the digestive system with its diseases as well as adjacent therapy for surgery has been revised.

RESULTS

Stem cells therapy may be used in the treatment of various diseases of different parts of the digestive system. This also applies to the end part of the digestive tract (proctological diseases) because stem cells can be used to treat fistulas. Liposuction allows more recovery of mesenchymal stem cells, compared to previous bone marrow harvesting methods. Despite the application of stem cells in the treatment of different diseases used for many years so far, the therapeutic use for the regeneration of the gastrointestinal tract is still rare and unfamiliar.

CONCLUSIONS

Regenerative medicine seems to be a promising tool in medical research, especially when insulated cells and designed biomaterials are taken into consideration. Major points of discussion include types of stem cells, their origin or differentiation for the treatment of many diseases.

摘要

背景

干细胞是一群具有自我更新能力和分化为人体中大量不同细胞的能力的细胞。此外,干细胞能够进行潜在的无限数量的分裂,这一特性在临床上至关重要。其具体应用领域包括治疗主要在血液学、骨科、外科、牙科和神经学领域的疾病。

材料与方法

在以下工作中,我们复习了有关干细胞治疗消化系统不同部位及其疾病的机制以及相邻手术治疗的最新知识。

结果

干细胞疗法可用于治疗消化系统不同部位的各种疾病。这也适用于消化道末端(肛肠疾病),因为干细胞可用于治疗瘘管。与以前的骨髓采集方法相比,抽脂术允许更多地回收间充质干细胞。尽管多年来一直在应用干细胞治疗各种疾病,但胃肠道再生的治疗用途仍然很少见且不熟悉。

结论

再生医学似乎是医学研究中很有前途的工具,特别是当考虑到隔离细胞和设计生物材料时。讨论的主要要点包括干细胞的类型、它们的起源或分化,用于治疗许多疾病。

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