Department of Hematology, Guangzhou First People's Hospital, Institutes for Life Sciences and School of Medicine, South China University of Technology, Guangzhou, China.
National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of China, Guangzhou, China.
Stem Cells. 2020 Jul;38(7):818-821. doi: 10.1002/stem.3173. Epub 2020 Mar 20.
The four transcription factors of the Yamanaka cocktail (Oct4, Sox2, Klf4, and Myc, termed OSKM) are famously capable of reprogramming somatic cells into induced pluripotent stem cells (iPSCs). In an article recently published in Nature Communications, Wang et al describe the unexpected discovery that short-term activation of OSKM expression in acute myeloid leukemia cells in vivo induces apoptosis while negligibly affecting normal hematopoietic stem and progenitor cells (Nat Commun 2019;10:5594). These findings have potential implications for novel anticancer strategies.
山中因子鸡尾酒（包含 Oct4、Sox2、Klf4 和 Myc，简称 OSKM）的这四种转录因子以能够将体细胞重编程为诱导多能干细胞（iPS 细胞）而闻名。在最近发表于《自然通讯》的一篇文章中，Wang 等人描述了一个意外的发现，即在体内急性髓系白血病细胞中短期激活 OSKM 表达会诱导细胞凋亡，而对正常造血干祖细胞的影响可以忽略不计。这些发现对新型抗癌策略具有潜在意义。
