Ophthalmology, Instituto de Olhos Santa Genoveva, Uberlândia, Brazil.
Departamento de Oftalmologia e Otorrinolaringologia, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Ocul Immunol Inflamm. 2021 Aug 18;29(6):1151-1153. doi: 10.1080/09273948.2020.1734213. Epub 2020 Mar 11.
: To report a case of unilateral acute idiopathic maculopathy (UAIM) following vaccination for type A influenza virus (H1N1).: Clinical, fundus autofluorescence (FAF), fluorescein angiography (FA) and optical coherence tomography (OCT) findings are presented.: A 25-year old white male presented with an acute decrease of vision in his left eye eight days after immunization with influenza A vaccine. Clinical evaluation revealed a deep yellowish-white lesion at the macula, early hyperfluorescence at the level of retinal pigment epithelium (RPE), and leakage and staining during the late phase of FA. OCT demonstrated disruption of the photoreceptor ellipsoid zone, as well as heterogeneous reflectivity changes and thickening at the level of the outer retina-RPE. Three months after presentation, fundus examination showed resolution of the yellowish foveal lesion, with persistence of mild RPE atrophic changes.: This is the first reported case of UAIM following H1N1 vaccination to date.
: 报告一例甲型流感病毒（H1N1）疫苗接种后单侧急性特发性黄斑病变（UAIM）。: 呈现临床、眼底自发荧光（FAF）、荧光素血管造影（FA）和光学相干断层扫描（OCT）的结果。: 一名 25 岁白人男性，在接种甲型流感疫苗后 8 天出现左眼视力急性下降。临床评估显示黄斑区有深黄色白色病变，视网膜色素上皮（RPE）水平早期高荧光，晚期 FA 出现渗漏和染色。OCT 显示光感受器椭圆体带中断，以及外视网膜-RPE 水平的异质反射变化和增厚。发病 3 个月后，眼底检查显示黄斑区黄色病灶消退，RPE 萎缩性改变轻微持续。: 这是迄今为止首例报道的 H1N1 疫苗接种后发生的 UAIM。
