Kuzmenko N V, Pliss M G, Galagudza M M, Tsyrlin V A
V.A.Almazov National Medical Research Centre, 2 Akkuratova str., St. Petersburg 197341, Russian Federation, e-mail:
I.P.Pavlov Saint Petersburg First State Medical University, 6-8 L'va Tolstogo str., St. Petersburg 197022, Russian Federation.
Adv Gerontol. 2019;32(6):964-975.
Age-related changes in thermoregulation occur due to the deterioration of the adaptive capacity of the cardiovascular system caused by remodeling of the vascular wall and myocardium, capillary density reduction, changes in the synthesis and clearance of neurotransmitters and vasoactive substances, as well as the inhibition of the vegetative mechanisms of hemodynamic parameters regulation. A common way to simulate hyper- and hypothermal conditions is to use a suit with tubes to fill with water at different temperatures. The purpose of this work is to conduct a meta-analysis of the hemodynamic parameters shifts when modeling hyper- and hypothermia using such a suit in people of different age groups. As a result of the meta-analysis, it was found that heating the whole body is accompanied by a decrease in blood pressure (BP) and an increase in heart rate (HR). The reaction of hemodynamic parameters to hyperthermia does not significantly change with aging. Cooling of the whole body is accompanied by an increase in BP without changing the HR. In hypothermia, the amplitude of the elevation of the systolic BP is greater in older people.
体温调节方面与年龄相关的变化是由于血管壁和心肌重塑导致心血管系统适应能力下降、毛细血管密度降低、神经递质和血管活性物质的合成及清除发生变化,以及血液动力学参数调节的自主机制受到抑制。模拟高温和低温条件的常用方法是使用带有管子的套装,通过注入不同温度的水来实现。这项工作的目的是对不同年龄组的人使用这种套装模拟高温和低温时血液动力学参数的变化进行荟萃分析。荟萃分析的结果发现,全身加热会伴随着血压(BP)下降和心率(HR)增加。血液动力学参数对高温的反应不会随着年龄增长而显著变化。全身冷却会伴随着血压升高而心率不变。在低温状态下,老年人收缩压升高的幅度更大。