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[老年视网膜色素变性患者的现代治疗方法(文献综述)。]

[Modern approaches to the retinitis pigmentosa treatment in the older age patients (literature review).].

作者信息

Derkach A V, Trofimova S V

机构信息

Saint-Petersburg Institute of Bioregulation and Gerontology, 3 Dynamo pr., St. Petersburg 197110, Russian Federation, e-mail:

出版信息

Adv Gerontol. 2019;32(6):1017-1022.

Abstract

Retinitis pigmentosa is a hereditary degenerative retina disease, often severe and affecting the retinal pigment epithelium and photoreceptor layer. For the older age group, the disease is increased by the addition of age-related degenerative processes in the retina. Due to the diversity of development factors and forms of retinitis pigmentosa, there is no uniform concept for treating a disease. Applying gene therapy and the optogenetic method is currently impossible because they are at the stage of experimental studies. For patients with terminal stage of retinitis pigmentosa, the implantation of a bionic eye is possible - a device with the ability to restore residual vision. The main treatment method is therapeutic. There were a lot of experimental and clinical studies of various drugs, the efficiency of which varies. Peptide bioregulators are actively used, they support the structural and functional homeostasis of cell populations and have a retinoprotective effect. It is also particularly important to improve the somatic condition of the patient through the use of peptide drugs in the complex.

摘要

视网膜色素变性是一种遗传性视网膜退行性疾病,通常较为严重,会影响视网膜色素上皮和光感受器层。对于老年群体而言,由于视网膜中与年龄相关的退行性病变过程,该疾病的发病率会增加。由于视网膜色素变性的发展因素和形式具有多样性,因此对于这种疾病的治疗没有统一的概念。目前应用基因治疗和光遗传学方法是不可能的,因为它们尚处于实验研究阶段。对于视网膜色素变性终末期的患者,可以植入仿生眼——一种具有恢复残余视力能力的装置。主要的治疗方法是药物治疗。针对各种药物进行了大量的实验和临床研究,其疗效各不相同。肽类生物调节剂被积极使用,它们维持细胞群体的结构和功能稳态,并具有视网膜保护作用。通过联合使用肽类药物来改善患者的身体状况也尤为重要。

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