主要头痛诊断的时间趋势和预测因素。来自三个北特伦德拉格健康调查的数据。
Time trends of major headache diagnoses and predictive factors. Data from three Nord-Trøndelag health surveys.
机构信息
Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Clinical Research Unit Central Norway, St. Olavs Hospital, Trondheim, Norway.
出版信息
J Headache Pain. 2020 Mar 11;21(1):24. doi: 10.1186/s10194-020-01095-5.
AIMS
The primary aim of this study was to investigate time trends of major headache diagnoses using cross-sectional data from two population-based health surveys. In addition, we aimed to perform a longitudinal assessment of baseline characteristics and subsequent risk for having headache at 22-years' follow-up among those participating in three health surveys.
METHODS
Data from the Nord-Trøndelag Health Study (HUNT) performed in 1995-1997 (HUNT2), 2006-2008 (HUNT3) and 2017-2019 (HUNT4) were used. The 1-year prevalence time trends of major headache diagnoses were estimated among 41,460 participants in HUNT4 and among 39,697 participants in HUNT3, two surveys with identical headache questions. 16,118 persons participated in all three surveys, and among these, a Poisson regression was used to evaluate health-related baseline information in HUNT2 and the risk ratios (RRs) with 95% confidence interval (CIs) of consistently reporting headache during follow-up.
RESULTS
Compared with the 1-year prevalence in HUNT3, a higher proportion of participants in HUNT4 had tension-type headache (20.7% vs. 15.9%, p < 0.001), whereas a lower 1-year prevalence was found for migraine (11.1% vs. 12.0%, p < 0.001) and medication overuse headache (MOH) (0.3% vs. 1.0%, p < 0.001). Participants in the age group 20-39 years at baseline nearly three times increased risk (RR = 2.8, 95% CI 2.5-3.1) of reporting headache in HUNT2, HUNT3 and HUNT4 than persons aged 50 years or more. Female sex, occurrence of chronic musculoskeletal complaints and high score of depression or anxiety at baseline doubled the risk of having headache in all three surveys.
CONCLUSIONS
The 1-year prevalence of migraine and MOH was lower in HUNT4 than in HUNT3. Young age, female sex, and occurrence of musculoskeletal complaints and high score of anxiety and/or depression were all associated with substantially increased risk of reporting headache in all three surveys.
目的
本研究的主要目的是使用两项基于人群的健康调查的横断面数据来研究主要头痛诊断的时间趋势。此外，我们旨在对参加三项健康调查的参与者进行基线特征的纵向评估，并在 22 年随访时评估后续发生头痛的风险。
方法
使用 1995-1997 年进行的北特伦德拉格健康研究（HUNT2）、2006-2008 年（HUNT3）和 2017-2019 年（HUNT4）的数据。在 HUNT4 中，我们估计了主要头痛诊断的 1 年患病率趋势，在 HUNT3 中，我们估计了 39697 名参与者的主要头痛诊断的 1 年患病率趋势，这两项调查均采用了相同的头痛问题。16118 人参加了所有三项调查，在这些人中，我们使用泊松回归评估了 HUNT2 中的健康相关基线信息，并评估了在随访期间持续报告头痛的风险比（RR）及其 95%置信区间（CI）。
结果
与 HUNT3 的 1 年患病率相比，HUNT4 中患有紧张型头痛的参与者比例更高（20.7% vs. 15.9%，p<0.001），而偏头痛（11.1% vs. 12.0%，p<0.001）和药物过度使用性头痛（MOH）（0.3% vs. 1.0%，p<0.001）的 1 年患病率则更低。基线时年龄在 20-39 岁的参与者报告在 HUNT2、HUNT3 和 HUNT4 中头痛的风险增加了近三倍（RR=2.8，95%CI 2.5-3.1），而年龄在 50 岁或以上的参与者则更低。在所有三项调查中，基线时患有慢性肌肉骨骼疾病、抑郁或焦虑评分较高的女性，其发生头痛的风险均增加了一倍。
结论
与 HUNT3 相比，HUNT4 中偏头痛和 MOH 的 1 年患病率更低。在所有三项调查中，年轻、女性、肌肉骨骼疾病以及焦虑和/或抑郁评分较高，均与报告头痛的风险显著增加有关。
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