State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Orthognathic and TMJ Surgery, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Stem Cell Res Ther. 2020 Mar 12;11(1):111. doi: 10.1186/s13287-020-01604-y.
Cartilage-derived pluripotent cells reside in hyaline cartilage and fibrocartilage. These cells have the potential for multidirectional differentiation; can undergo adipogenesis, osteogenesis, and chondrogenesis; and have been classified as mesenchymal stem cells (MSCs) conforming to the minimal criteria of the International Society for Cellular Therapy. Cartilage tissue is prone to injury and is difficult to repair. As cartilage-derived pluripotent cells are the closest cell source to cartilage tissue, they are expected to have the strongest ability to differentiate into cartilage compared to other MSCs. This review focuses on the organizational distribution, expression, and function of cartilage-derived pluripotent cells in joint development and repair to help explore the therapeutic potential of in situ cartilage-derived pluripotent cells for joint cartilage repair.
软骨多能细胞存在于透明软骨和纤维软骨中。这些细胞具有多向分化的潜能；能够进行脂肪生成、成骨和软骨生成；并已被归类为符合国际细胞治疗学会最小标准的间充质干细胞 (MSCs)。软骨组织容易受伤且难以修复。由于软骨多能细胞是最接近软骨组织的细胞来源，与其他 MSCs 相比，它们有望具有最强的分化为软骨的能力。本综述重点介绍了软骨多能细胞在关节发育和修复中的组织分布、表达和功能，以帮助探索原位软骨多能细胞治疗关节软骨修复的治疗潜力。
