Li Na, Liu Xinlu
1st Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, People's Republic of China.
1st Department of General Surgery, First Affiliated Hospital of Dalian Medical University, Dalian 116011, People's Republic of China.
Onco Targets Ther. 2020 Feb 27;13:1787-1795. doi: 10.2147/OTT.S238920. eCollection 2020.
Phosphoglycerate mutase 1 (PGAM1) is an important enzyme that catalyzes the reversible conversion of 3-phosphoglycerate and 2-phosphoglycerate during the process of glycolysis. Increasing evidence suggests that PGAM1 is widely overexpressed in various cancer tissues and plays a significant role in promoting cancer progression and metastasis. Although PGAM1 is a potential target in cancer therapy, the specific mechanisms of action remain unknown. This review introduces the basic structure and functions of PGAM1 and its family members and summarizes recent advances in the role of PGAM1 and various inhibitors of cancer cell proliferation and metastasis from a glycolytic and non-glycolytic perspective. Recent studies have highlighted a correlation between PGAM1 and clinical features and prognosis of cancer as well as the development of target drugs for PGAM1. The integrated information in this review will help better understand the specific roles of PGAM1 in cancer progression. Furthermore, the information highlights the non-glycolytic functions of PGAM1 in tumor metastasis, providing an innovative basis and direction for clinical drug research.
磷酸甘油酸变位酶1（PGAM1）是一种重要的酶，在糖酵解过程中催化3-磷酸甘油酸和2-磷酸甘油酸的可逆转化。越来越多的证据表明，PGAM1在各种癌组织中广泛过度表达，并在促进癌症进展和转移中发挥重要作用。尽管PGAM1是癌症治疗中的一个潜在靶点，但其具体作用机制仍不清楚。本文综述介绍了PGAM1及其家族成员的基本结构和功能，并从糖酵解和非糖酵解的角度总结了PGAM1在癌细胞增殖和转移中的作用以及各种抑制剂的最新研究进展。最近的研究突出了PGAM1与癌症临床特征和预后之间的相关性以及PGAM1靶向药物的开发。本文综述中的综合信息将有助于更好地理解PGAM1在癌症进展中的具体作用。此外，这些信息突出了PGAM1在肿瘤转移中的非糖酵解功能，为临床药物研究提供了创新依据和方向。
