Department of Animal Science, Tokyo University of Agriculture, Atsugi, Japan.
Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.
Front Endocrinol (Lausanne). 2020 Feb 25;11:80. doi: 10.3389/fendo.2020.00080. eCollection 2020.
Reproduction involves tightly regulated series of events and the immune system is involved in an array of reproductive processes. Disruption of well-controlled immune functions leads to infertility, placental inflammation, and numerous pregnancy complications, including preeclampsia (PE). Inflammasomes are involved in the process of pathogen clearance and sterile inflammation. They are large multi-protein complexes that are located in the cytosol and play key roles in the production of the pivotal inflammatory cytokines, interleukin (IL)-1β and IL-18, and pyroptosis. The nucleotide-binding oligomerization domain, leucine-rich repeat-, and pyrin domain-containing 3 (NLRP3) inflammasome is a key mediator of sterile inflammation induced by various types of damage-associated molecular patterns (DAMPs). Recent evidence indicates that the NLRP3 inflammasome is involved in pregnancy dysfunction, including PE. Many DAMPs (uric acid, palmitic acid, high-mobility group box 1, advanced glycation end products, extracellular vesicles, cell-free DNA, and free fatty acids) are increased and associated with pregnancy complications, especially PE. This review focuses on the role of the NLRP3 inflammasome in the pathophysiology of PE.
生殖涉及一系列严格调控的事件，免疫系统参与多种生殖过程。免疫功能的失调会导致不孕、胎盘炎症和许多妊娠并发症，包括子痫前期 (PE)。炎症小体参与病原体清除和无菌性炎症的过程。它们是位于细胞质中的大型多蛋白复合物，在产生关键炎症细胞因子白细胞介素 (IL)-1β 和 IL-18 以及细胞焦亡方面发挥着关键作用。核苷酸结合寡聚化结构域、富含亮氨酸重复序列和pyrin 结构域包含 3（NLRP3）炎症小体是各种损伤相关分子模式（DAMPs）诱导的无菌性炎症的关键介质。最近的证据表明，NLRP3 炎症小体参与妊娠功能障碍，包括 PE。许多 DAMPs（尿酸、棕榈酸、高迁移率族蛋白框 1、晚期糖基化终产物、细胞外囊泡、无细胞 DNA 和游离脂肪酸）增加，并与妊娠并发症，特别是 PE 相关。这篇综述重点介绍了 NLRP3 炎症小体在 PE 病理生理学中的作用。
