Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin, China.
Front Immunol. 2024 Sep 16;15:1400977. doi: 10.3389/fimmu.2024.1400977. eCollection 2024.
Pyroptosis is a form of programmed cell death that is crucial in the development of various diseases, including autoimmune diseases, atherosclerotic diseases, cancer, and pregnancy complications. In recent years, it has gained significant attention in national and international research due to its association with inflammatory immune overactivation and its involvement in pregnancy complications such as miscarriage and preeclampsia (PE). The mechanisms discussed include the canonical pyroptosis pathway of gasdermin activation and pore formation (caspase-1-dependent pyroptosis) and the non-canonical pyroptosis pathway (cysteoaspartic enzymes other than caspase-1). These pathways work on various cellular and factorial levels to influence normal pregnancy. This review aims to summarize and analyze the pyroptosis pathways associated with abnormal pregnancies and pregnancy complications. The objective is to enhance pregnancy outcomes by identifying various targets to prevent the onset of pyroptosis.
细胞焦亡是一种重要的程序性细胞死亡方式，与多种疾病的发生发展密切相关，包括自身免疫性疾病、动脉粥样硬化性疾病、癌症和妊娠并发症等。近年来，由于其与炎症性免疫过度激活的关系以及在妊娠并发症（如流产和子痫前期）中的作用，细胞焦亡受到国内外研究的广泛关注。讨论的机制包括 Gasdermin 激活和孔形成的经典细胞焦亡途径（依赖半胱天冬酶-1 的细胞焦亡）和非经典细胞焦亡途径（除半胱天冬酶-1 以外的胱天冬酶酶）。这些途径在多个细胞和因子水平上发挥作用，影响正常妊娠。本综述旨在总结和分析与异常妊娠和妊娠并发症相关的细胞焦亡途径。目的是通过确定各种预防细胞焦亡发生的靶点来改善妊娠结局。
