Department of Cardiology, Zibo Central Hospital, Shandong University, No. 10, Sonth Shanghai Road, Zibo, 255000, People's Republic of China.
Binzhou Medical University, No. 346, Guanhai Road, Laishan District, Yantai, 264003, Shandong, People's Republic of China.
Clin Res Cardiol. 2020 May;109(5):531-538. doi: 10.1007/s00392-020-01626-9. Epub 2020 Mar 11.
Studies have reminded that cardiovascular metabolic comorbidities made patients more susceptible to suffer 2019 novel corona virus (2019-nCoV) disease (COVID-19), and exacerbated the infection. The aim of this analysis is to determine the association of cardiovascular metabolic diseases with the development of COVID-19.
A meta-analysis of eligible studies that summarized the prevalence of cardiovascular metabolic diseases in COVID-19 and compared the incidences of the comorbidities in ICU/severe and non-ICU/severe patients was performed. Embase and PubMed were searched for relevant studies.
A total of six studies with 1527 patients were included in this analysis. The proportions of hypertension, cardia-cerebrovascular disease and diabetes in patients with COVID-19 were 17.1%, 16.4% and 9.7%, respectively. The incidences of hypertension, cardia-cerebrovascular diseases and diabetes were about twofolds, threefolds and twofolds, respectively, higher in ICU/severe cases than in their non-ICU/severe counterparts. At least 8.0% patients with COVID-19 suffered the acute cardiac injury. The incidence of acute cardiac injury was about 13 folds higher in ICU/severe patients compared with the non-ICU/severe patients.
Patients with previous cardiovascular metabolic diseases may face a greater risk of developing into the severe condition and the comorbidities can also greatly affect the prognosis of the COVID-19. On the other hand, COVID-19 can, in turn, aggravate the damage to the heart.
研究提醒，心血管代谢合并症使患者更容易感染 2019 年新型冠状病毒（2019-nCoV）疾病（COVID-19），并使感染恶化。本分析旨在确定心血管代谢疾病与 COVID-19 发展之间的关联。
对总结 COVID-19 中心血管代谢疾病患病率并比较 ICU/重症和非 ICU/重症患者合并症发生率的合格研究进行荟萃分析。检索 Embase 和 PubMed 相关研究。
共有 6 项研究纳入了 1527 名患者。COVID-19 患者中高血压、心脑血管疾病和糖尿病的比例分别为 17.1%、16.4%和 9.7%。高血压、心脑血管疾病和糖尿病的发生率在 ICU/重症病例中分别约为两倍、三倍和两倍，而非 ICU/重症病例中则较高。至少有 8.0%的 COVID-19 患者发生急性心脏损伤。急性心脏损伤在 ICU/重症患者中的发生率比非 ICU/重症患者高约 13 倍。
患有既往心血管代谢疾病的患者可能面临更大的发展为重症的风险，合并症也会极大地影响 COVID-19 的预后。另一方面，COVID-19 反过来又会加重对心脏的损害。
