Hansson P, Ekblom A, Lindblom U, Marchettini P
Department of Physiology II, Karolinska Institutet, Stockholm, Sweden.
J Neurol Neurosurg Psychiatry. 1988 Aug;51(8):1032-6. doi: 10.1136/jnnp.51.8.1032.
Cutaneous sensibility was tested in eight patients suffering from acute postoperative intraoral pain. Tactile-, cold-, warm-, and heat-pain thresholds as well as reaction time to cold pulses were unaffected by the presence of pain. However, reaction time to warm pulses was increased in the painful area on the day of pain compared to a non-painful state. The findings are discussed in relation to (1) functional convergence of different sensory fibres on central neurons (2) the phenomenon of diffuse noxious inhibitory controls and (3) secondary hyperalgesia. The observed effect of clinical pain on the warm pathway could be explained as an intrasegmental noxious inhibitory effect.
对8例急性术后口腔内疼痛患者的皮肤感觉功能进行了测试。触觉、冷觉、温觉和热痛阈值以及对冷脉冲的反应时间不受疼痛存在的影响。然而，与无痛状态相比，疼痛当天疼痛区域对热脉冲的反应时间延长。结合以下方面对这些发现进行了讨论：(1)不同感觉纤维在中枢神经元上的功能汇聚；(2)弥漫性伤害性抑制控制现象；(3)继发性痛觉过敏。临床疼痛对热觉传导通路的观察效应可解释为节段内伤害性抑制效应。
