Ekblom A, Hansson P
Department of Physiology II, Karolinska Institutet, Stockholm, Sweden.
J Neurol Neurosurg Psychiatry. 1987 Sep;50(9):1216-20. doi: 10.1136/jnnp.50.9.1216.
The effect of conditioning stimulation on thermal sensitivity and clinical pain was studied in 40 patients and six healthy subjects. Thresholds regarding cold, warm and heat pain perception did not differ significantly between the painful and non-painful skin areas in patients or between patients and healthy subjects before stimulation. The patients received either 100 Hz TENS, 2 Hz TENS, 100 Hz vibration, or placebo. No significant changes in thermal sensitivity were observed during and after conditioning stimulation in any of the test groups, although 24/40 (60%) of the patients reported reduction of their clinical pain intensity. The results indicate that (a) thermal sensitivity is not influenced by the presence of clinical pain, (b) the effects of stimulation on thermal sensitivity (thresholds) and clinical pain are not closely related, (c) central inhibitory effects of TENS and vibration are crucial for their pain relieving capacity.
对40例患者和6名健康受试者研究了条件刺激对热敏感性和临床疼痛的影响。在刺激前，患者疼痛和非疼痛皮肤区域之间以及患者与健康受试者之间，冷、温及热痛觉阈值无显著差异。患者接受100Hz经皮电刺激神经疗法（TENS）、2Hz TENS、100Hz振动或安慰剂治疗。尽管40例患者中有24例（60%）报告其临床疼痛强度降低，但在任何测试组的条件刺激期间及之后均未观察到热敏感性有显著变化。结果表明：（a）热敏感性不受临床疼痛存在的影响；（b）刺激对热敏感性（阈值）和临床疼痛的影响并非密切相关；（c）TENS和振动的中枢抑制作用对其止痛能力至关重要。
