副球孢子菌病患者中HLA - B40频率增加。
Increased frequency of HLA-B40 in patients with paracoccidioidomycosis.
作者信息
Lacerda G B, Arce-Gomez B, Telles Filho F Q
机构信息
Departamento de Genética, Universidade Federal do Paraná, Curitaba-PR, Brazil.
出版信息
J Med Vet Mycol. 1988;26(4):253-6. doi: 10.1080/02681218880000351.
The presence of 9 HLA-A and 14 HLA-B specificities was determined in 83 patients with paracoccidioidomycosis. The finding of a higher than normal incidence of HLA-B40 (chi 2 = 10.8; corrected P less than 0.026) supports the hypothesis that genetic factors may play a role in susceptibility to paracoccidioidomycosis. The risk of developing paracoccidioidomycosis is 4.3 times higher for individuals carrying HLA-B40 than for those lacking this antigen.
在83例副球孢子菌病患者中测定了9种HLA - A和14种HLA - B特异性。HLA - B40发生率高于正常（卡方= 10.8；校正P值小于0.026）这一发现支持了遗传因素可能在副球孢子菌病易感性中起作用的假说。携带HLA - B40的个体患副球孢子菌病的风险是缺乏该抗原个体的4.3倍。
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