Miyamoto K, Ishii H, Takata H, Takagi S, Shigeta Y, Sekiguchi S, Suyama K, Kohno H, Tsuchiya M
Pharmacol Biochem Behav. 1983;18 Suppl 1:467-71. doi: 10.1016/0091-3057(83)90219-8.
Seventy-seven chronic alcoholics with liver disease were studied to evaluate the HLA antigen association. There were no significant differences of HLA antigen phenotype frequencies (PF) between the patients and controls regarding A and C loci, (62 healthy Japanese). Prevalences of HLA-B40 complex (B40 . 48 . 13) and DRW9 tended to increase among chronic alcoholics. When chronic alcoholics were divided according to whether they had liver cirrhosis or not, the cirrhosis group (42 cases) revealed a significantly higher frequency of HLA-DRW9 (chi 2 = 10.88, p less than 0.001, corrected p less than 0.05, relative risk (R.R.) = 4.17) as compared to controls. There was also a tendency of B40 complex to increase in frequency (chi 2 = 5.51, p less than 0.05, R.R. = 2.65) in the cirrhosis group. Haplotype frequency and linkage disequilibrium parameters of HLA-B40 . 48-DRW9 were significantly higher than those of controls. Moreover, the increased frequency of DRW9 in the cirrhosis group was similar to that in autoimmune disease like ulcerative colitis or SLE. These data suggest that HLA-DRW9 and/or HLA-B40-DRW9 might be closely associated with susceptibility to developing alcoholic cirrhosis and that autoimmune mechanisms might be involved partly in its etiology.
对77名患有肝病的慢性酗酒者进行了研究，以评估HLA抗原的关联性。在A和C位点方面，患者与对照组（62名健康日本人）的HLA抗原表型频率（PF）没有显著差异。慢性酗酒者中HLA - B40复合体（B40、48、13）和DRW9的患病率有上升趋势。当根据是否患有肝硬化将慢性酗酒者分组时，肝硬化组（42例）与对照组相比，HLA - DRW9的频率显著更高（卡方值 = 10.88，p < 0.001，校正后p < 0.05，相对风险（R.R.） = 4.17）。在肝硬化组中，B40复合体的频率也有上升趋势（卡方值 = 5.51，p < 0.05，R.R. = 2.65）。HLA - B40、48 - DRW9的单倍型频率和连锁不平衡参数显著高于对照组。此外，肝硬化组中DRW9频率的增加与溃疡性结肠炎或系统性红斑狼疮等自身免疫性疾病中的情况相似。这些数据表明，HLA - DRW9和/或HLA - B40 - DRW9可能与酒精性肝硬化的易感性密切相关，并且自身免疫机制可能部分参与其病因。
