Huang Rongfu, Yao Jianfeng, Ding Xin, Liu Jiangyi, Fan Chunmei, Duan Hongbin, Ye Huiming
Clin Lab. 2020 Mar 1;66(3). doi: 10.7754/Clin.Lab.2019.190528.
YKL-40, a chitinase-like glycoprotein has been identified as a candidate tumor marker. The current study evaluated the clinical significance of plasma YKL-40 in esophageal cancer patients.
We enrolled 127 esophageal cancer patients, 29 healthy controls. Plasma YKL-40 levels were measured through enzyme linked immunosorbent assay. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic efficiency of plasma YKL-40 in esophageal cancer patients. The correlations between plasma YKL-40 and clinicopathological characteristics of esophageal were analyzed.
Plasma YKL-40 levels were significantly higher in patients with lymph node metastasis than those that were non-metastatic (p = 0.005). Patients with tumor thrombus formation presented with significantly higher YKL-40 levels than those without thrombus formation (160.3 vs. 74.7 ng/mL, p = 0.012). YKL-40 levels in patients with advanced stage (III and IV) were significantly higher than those in the early stages (I and II, p = 0.016). ROC curve analysis showed that the area under curve was 0.909, and the best diagnostic threshold of YKL-40 for esophageal cancer was 80.6 ng/mL with 68.9% sensitivity and 96.6% specificity.
This study indicated that YKL-40 may be a biomarker for esophageal cancer and potential biomarker for identification of invasive esophageal cancer.
YKL-40，一种几丁质酶样糖蛋白，已被确定为候选肿瘤标志物。本研究评估了食管癌患者血浆YKL-40的临床意义。
我们纳入了127例食管癌患者和29例健康对照者。通过酶联免疫吸附测定法测量血浆YKL-40水平。采用受试者工作特征（ROC）曲线分析来评估血浆YKL-40在食管癌患者中的诊断效率。分析血浆YKL-40与食管癌临床病理特征之间的相关性。
有淋巴结转移的患者血浆YKL-40水平显著高于无转移者（p = 0.005）。有肿瘤血栓形成的患者YKL-40水平显著高于无血栓形成者（160.3对74.7 ng/mL，p = 0.012）。晚期（III期和IV期）患者的YKL-40水平显著高于早期（I期和II期，p = 0.016）。ROC曲线分析显示曲线下面积为0.909，YKL-40对食管癌的最佳诊断阈值为80.6 ng/mL，敏感性为68.9%，特异性为96.6%。
本研究表明YKL-40可能是食管癌的生物标志物以及识别侵袭性食管癌的潜在生物标志物。
