School of Speech, Language, and Hearing Sciences, San Diego State University, CA.
College of Health and Human Services, San Diego State University, CA.
J Speech Lang Hear Res. 2020 Mar 23;63(3):885-895. doi: 10.1044/2019_JSLHR-19-00180. Epub 2020 Mar 12.
Purpose The purpose of this study was to examine marijuana or other substance use on pure-tone thresholds and distortion product otoacoustic emissions (DPOAEs) in young adults. Method Young adults ( = 243; 182 women, 61 men; = 20.9 years, = 2.7 years) participated in this study. Survey data included personal music system use, marijuana use, and misuse of prescription medications. Otoscopy, tympanometry, pure-tone audiometry, and DPOAEs were obtained. Pure tones from octave frequencies of 0.25 through 8 kHz were obtained, and DPOAEs were recorded between f frequencies of 1 and 6 kHz using two continuously presented stimulus tones swept in frequency. Results Those who reported marijuana or stimulant use had similar pure-tone averages (0.5, 1, 2, and 4 kHz) compared to those who reported never using marijuana or stimulants. Women who reported marijuana use in the past 30 days > two times had statistically significant higher mean DPOAEs compared to women who reported ≤ two times or no marijuana use in the past 30 days. Men, however, who reported marijuana use in the past 30 days > two times had lower, but not statistically significant, mean DPOAEs compared to men who reported ≤ two times or no marijuana use in the past 30 days. Women who reported ever using stimulants had statistically significant higher mean DPOAEs compared to women who reported never using stimulants; for men, mean DPOAEs were similar between those who reported ever using stimulants and those who never used stimulants. Conclusions The results of this study demonstrate different and contradictory associations between marijuana use, stimulant use, and hearing outcomes as a function of sex. Future research is needed to explore these associations utilizing larger sample sizes while accounting for additional harmful exposures to other noise exposures.
目的 本研究旨在探讨年轻人吸食大麻或其他物质对纯音阈值和畸变产物耳声发射（DPOAE）的影响。 方法 本研究纳入了 243 名年轻人（182 名女性，61 名男性；年龄均值为 20.9 岁，标准差为 2.7 岁）。调查问卷内容包括个人音乐系统使用情况、大麻使用情况以及处方药物滥用情况。所有参与者均接受耳镜检查、鼓室图测试、纯音测听和 DPOAE 检测。通过 0.25 至 8 kHz 的 8 个倍频程的纯音进行测试，通过两个连续呈现的刺激音在频率上进行扫频来记录 1 至 6 kHz 之间的 DPOAE。 结果 与从未使用过大麻或兴奋剂的人相比，报告过去 30 天内使用过大麻或兴奋剂超过 2 次的人在纯音平均阈值（0.5、1、2 和 4 kHz）方面无显著差异。然而，报告过去 30 天内使用过大麻超过 2 次的女性 DPOAE 均值显著高于报告过去 30 天内使用大麻 ≤ 2 次或未使用大麻的女性，但男性报告过去 30 天内使用过大麻超过 2 次的男性 DPOAE 均值则低于报告过去 30 天内使用大麻 ≤ 2 次或未使用大麻的男性，但差异无统计学意义。报告曾经使用过兴奋剂的女性 DPOAE 均值显著高于报告从未使用过兴奋剂的女性；而对于男性，报告曾经使用过兴奋剂和从未使用过兴奋剂的男性 DPOAE 均值无显著差异。 结论 本研究结果表明，大麻使用、兴奋剂使用与听力结果之间存在不同且相互矛盾的关联，且这种关联因性别而异。未来需要开展更多的研究，以在考虑其他噪声暴露等有害因素的情况下，利用更大的样本量来探索这些关联。
