Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany.
Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany.
Drug Alcohol Depend. 2020 Apr 1;209:107898. doi: 10.1016/j.drugalcdep.2020.107898. Epub 2020 Feb 5.
Alcohol dependence affects metabolic processes. Further research is needed to apply this knowledge clinically. In this study, possible differences in serum lipids and/or leptin activities between alcohol-dependent in-patients and healthy controls and possible associations with alcohol-related blood parameters and with prospective outcomes in alcohol dependence were assessed sex-specifically.
We measured and compared (median) serum lipids (triglycerides and total, HDL, and LDL cholesterol) and leptin activities (leptin, soluble leptin receptor [ObRe], and free leptin index) in 200 (males 56.5 %) early-abstinent alcohol-dependent in-patients and 240 (males 55.4 %) healthy controls and assessed alcohol-related readmissions during a 24 -month post-inclusion period.
Male patients showed higher HDL cholesterol (61 versus 48 mg/dl), lower LDL/HDL ratios (2.06 versus 3.04), and lower free leptin index (0.30 versus 0.59) at study inclusion compared to healthy controls. In patients, ObRe levels were higher than in controls and decreased from inclusion to the second study-visit (at median 5 days later; males: 16.7-13.8 versus 11.0 ng/ml; females: 17.0-13.4 versus 12.1 ng/ml). The free leptin index increased between the two time points in females (0.80 versus 1.20). Lipids and leptin activities correlated with carbohydrate-deficient transferrin levels and liver enzyme activities. None of the serum parameters were significantly associated with alcohol-related readmissions.
Our data support that serum lipid levels and leptin activities are involved in alcohol dependence. The parameters appear as possible indirect biomarkers for alcohol dependence.
酒精依赖会影响代谢过程。需要进一步的研究将这一知识应用于临床。本研究旨在评估酒精依赖住院患者和健康对照者的血清脂质和/或瘦素活性是否存在差异，以及这些差异与酒精相关的血液参数和酒精依赖的预后是否存在关联。
我们测量并比较了 200 名（男性占 56.5%）早期戒酒的酒精依赖住院患者和 240 名（男性占 55.4%）健康对照者的血清脂质（甘油三酯和总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇）和瘦素活性（瘦素、可溶性瘦素受体[ObRe]和游离瘦素指数），并在 24 个月的纳入后评估了与酒精相关的再入院情况。
与健康对照组相比，男性患者在研究纳入时的高密度脂蛋白胆固醇水平较高（61 与 48mg/dl），低密度脂蛋白/高密度脂蛋白比值较低（2.06 与 3.04），游离瘦素指数较低（0.30 与 0.59）。患者的 ObRe 水平高于对照组，且从纳入到第二次研究就诊时（中位数为 5 天后）下降（男性：16.7-13.8 与 11.0ng/ml；女性：17.0-13.4 与 12.1ng/ml）。女性患者的游离瘦素指数在两个时间点之间增加（0.80 与 1.20）。脂质和瘦素活性与转铁蛋白缺乏和肝酶活性相关。血清参数均与酒精相关的再入院无显著相关性。
本研究数据支持血清脂质水平和瘦素活性与酒精依赖有关。这些参数可能是酒精依赖的间接生物标志物。
