Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia.
J Sleep Res. 2020 Apr;29(2):e12953. doi: 10.1111/jsr.12953. Epub 2019 Dec 3.
Research into insomnia disorder has pointed to large-scale brain network dysfunctions. Dynamic functional connectivity is instrumental to cognitive functions but has not been investigated in insomnia disorder. This study assessed between-network functional connectivity strength and variability in patients with insomnia disorder as compared with matched controls without sleep complaints. Twelve-minute resting-state functional magnetic resonance images and T1-weighed images were acquired in 65 people diagnosed with insomnia disorder (21-69 years, 48 female) and 65 matched controls without sleep complaints (22-70 years, 42 female). Pairwise correlations between the activity time series of 14 resting-state networks and temporal variability of the correlations were compared between cases and controls. After false discovery rate correction for multiple comparisons, people with insomnia disorder and controls did not differ significantly in terms of mean between-network functional connectivity strength; people with insomnia disorder did, however, show less functional connectivity variability between the anterior salience network and the left executive-control network. The finding suggests less flexible interactions between the networks during the resting state in people with insomnia disorder.
研究指出，失眠症与大规模脑网络功能障碍有关。动态功能连接对于认知功能至关重要，但在失眠症中尚未进行研究。本研究比较了失眠症患者与无睡眠抱怨的匹配对照组之间的网络间功能连接强度和可变性。在 65 名被诊断为失眠症的患者（21-69 岁，48 名女性）和 65 名匹配的无睡眠抱怨的对照组（22-70 岁，42 名女性）中，采集了 12 分钟的静息状态功能磁共振成像和 T1 加权图像。在病例组和对照组之间比较了 14 个静息状态网络的活动时间序列之间的成对相关性及其相关性的时间可变性。在对多个比较进行虚假发现率校正后，失眠症患者和对照组在平均网络间功能连接强度方面没有显著差异；然而，失眠症患者在前注意网络和左执行控制网络之间的功能连接可变性较小。这一发现表明，在失眠症患者的静息状态下，网络之间的相互作用不太灵活。
