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[丙型肝炎防治指南(2019年版)要点]

[Highlights of the guidelines of prevention and treatment for hepatitis C (2019 version)].

作者信息

Rao H Y, Duan Z P, Wang G Q, Wei L

机构信息

Peking University People's Hospital, Peking University Hepatology Institute, Beijing 100044, China.

Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2020 Feb 20;28(2):129-132. doi: 10.3760/cma.j.issn.1007-3418.2020.02.005.

Abstract

The key points from the updated guideline of prevention and treatment for hepatitis C (2019 version) is compared with the previous hepatitis C guideline. A new terminology and the World Health Organization's goal of eliminating viral hepatitis as a public-health threat by 2030 are stressed. In the prevention section, the screening for hepatitis C virus infection in high-risk population is the primary means of prevention, emphasizing that treatment, is prevention. In the aspect of treatment, pangenotypic interferon-free scheme are initial recommendations. In addition, it also introduces our country independent research and development on direct-acting antiviral agents, and antiviral therapy schedule for many special populations, including decompensated liver cirrhosis, chronic kidney disease, children and adolescents combined with chronic kidney injury, HBV infection-before and after liver transplantation, treatment failure, and acute hepatitis C. A simplified on-treatment monitoring schedule, especially genotype 3 prevalent in Southwest part of our country is introduced.

摘要

将丙型肝炎防治更新指南(2019年版)的要点与既往丙型肝炎指南进行比较。强调了新术语以及世界卫生组织到2030年消除病毒性肝炎作为公共卫生威胁的目标。在预防部分,对高危人群进行丙型肝炎病毒感染筛查是主要预防手段,强调治疗即预防。在治疗方面,泛基因型无干扰素方案是初始推荐。此外,还介绍了我国自主研发的直接抗病毒药物以及针对许多特殊人群的抗病毒治疗方案,包括失代偿期肝硬化、慢性肾脏病、合并慢性肾损伤的儿童和青少年、肝移植前后的HBV感染、治疗失败以及急性丙型肝炎。介绍了简化的治疗期间监测方案,尤其是在我国西南部流行的基因3型。

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