Department of Infectious Disease, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Antiviral Therapy Center, The First People's Hospital of Yuexi County, Liangshan, China.
J Int Assoc Provid AIDS Care. 2023 Jan-Dec;22:23259582231217810. doi: 10.1177/23259582231217810.
The present study aimed to characterize the genotype distribution and clinical characteristics of HCV monoinfected and HCV/HIV coinfected patients in the Liangshan Prefecture, Sichuan Province, China. All the patients were divided into HCV monoinfection and HCV/HIV coinfection groups according to whether they were complicated with HIV infection. The data from the two groups were collected. In this study, HCV genotype 3 was the most common genotype in both groups, while HCV genotype 6 was significantly higher in the coinfection group than in the monoinfection group (= 0.046). The white blood cell count, total bilirubin level, and HCV RNA were significantly higher in the HCV monoinfection group than that in the HCV/HIV coinfection group (= 0.031; < 0.001; = 0.027, respectively). HCV prevalence was high in HIV-positive patients in the Liangshan Prefecture. Thus, incorporating screening and management of HCV monoinfection and HCV/HIV coinfection is needed in local region programs.
本研究旨在描述中国四川省凉山州 HCV 单感染和 HCV/HIV 合并感染患者的基因型分布和临床特征。所有患者根据是否合并 HIV 感染分为 HCV 单感染组和 HCV/HIV 合并感染组，收集两组数据。在本研究中，两组均以 HCV 基因型 3 最为常见，而 HCV 基因型 6 在合并感染组中的比例明显高于单感染组（=0.046）。HCV 单感染组的白细胞计数、总胆红素水平和 HCV RNA 均显著高于 HCV/HIV 合并感染组（=0.031；<0.001；=0.027，分别）。在凉山州，HIV 阳性患者的 HCV 流行率较高。因此，当地的项目需要将 HCV 单感染和 HCV/HIV 合并感染的筛查和管理纳入其中。
