Lee Yu Ran, Joo Hee Kyoung, Jeon Byeong Hwa
Research Institute for Medical Sciences, College of Medicine, Chungnam National University, 266 Munhwa-ro, Jung-gu, Daejeon 35015, Korea.
Department of Physiology, College of Medicine, Chungnam National University, 266 Munhwa-ro, Jung-gu, Daejeon 35015, Korea.
Biomedicines. 2020 Mar 10;8(3):57. doi: 10.3390/biomedicines8030057.
Endothelial dysfunction promotes vascular inflammation by inducing the production of reactive oxygen species and adhesion molecules. Vascular inflammation plays a key role in the pathogenesis of vascular diseases and atherosclerotic disorders. However, whether there is an endogenous system that can participate in circulating immune surveillance or managing a balance in homeostasis is unclear. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (henceforth referred to as APE1/Ref-1) is a multifunctional protein that can be secreted from cells. It functions as an apurinic/apyrimidinic endonuclease in the DNA base repair pathway and modulates redox status and several types of transcriptional factors, in addition to its anti-inflammatory activity. Recently, it was reported that the secretion of APE1/Ref-1 into the extracellular medium of cultured cells or its presence in the plasma can act as a serological biomarker for certain disorders. In this review, we summarize the possible biological functions of APE1/Ref-1 according to its subcellular localization or its extracellular secretions, as therapeutic targets for vascular inflammation and as a serologic biomarker.
内皮功能障碍通过诱导活性氧和黏附分子的产生促进血管炎症。血管炎症在血管疾病和动脉粥样硬化疾病的发病机制中起关键作用。然而，尚不清楚是否存在一种内源性系统能够参与循环免疫监视或维持体内平衡的平衡。脱嘌呤/脱嘧啶内切核酸酶1/氧化还原因子-1（以下简称APE1/Ref-1）是一种可从细胞分泌的多功能蛋白质。它在DNA碱基修复途径中作为脱嘌呤/脱嘧啶内切核酸酶发挥作用，除了具有抗炎活性外，还能调节氧化还原状态和几种转录因子。最近有报道称，APE1/Ref-1分泌到培养细胞的细胞外培养基中或其存在于血浆中可作为某些疾病的血清生物标志物。在这篇综述中，我们根据APE1/Ref-1的亚细胞定位或细胞外分泌情况，总结了其可能的生物学功能，作为血管炎症的治疗靶点和血清生物标志物。
