单核细胞-高密度脂蛋白胆固醇比值与甲状腺结节的存在和大小有关，而与性别无关。
Monocyte-to-high-density lipoprotein cholesterol ratio is associated with the presence and size of thyroid nodule irrespective of the gender.
机构信息
Hangzhou Aeronautical Sanatorium of Chinese Air Force, Hangzhou, No. 27, Yang Gong Di, Xihu District, Zhejiang, 310007, Hangzhou, China.
Department of Rheumatology, Changhai Hospital, Naval Military Medical University (The Second Military Medical University), No. 168 Changhai Road, Yangpu District, Shanghai, 200433, China.
出版信息
Lipids Health Dis. 2020 Mar 12;19(1):36. doi: 10.1186/s12944-020-1196-z.
BACKGROUND
Systemic inflammation may be involved in the formation and progression of thyroid nodule (TN). The aim of this large-scale study was to investigate the association of several simple inflammatory markers with the presence and size of TN.
METHODS
A total of 133,698 adults were included for the current analysis. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) were calculated. The logistic regression was used to explore the association of the four markers with the presence and size of TN.
RESULTS
The prevalence of TN was 55.1% among females and 44% among males; 13% of women and 8% of men had non-micronodule. In women, MHR and PLR were significantly associated with the presence of TN and non-micronodule; in men, MHR and NLR were significantly associated with the presence of TN and non-micronodule.
CONCLUSIONS
As a low-cost, simple, and reproducible inflammatory marker, MHR is strongly associated with the presence and size of TN irrespective of the gender.
背景
全身性炎症可能参与甲状腺结节（TN）的形成和进展。本大规模研究的目的是探讨几种简单的炎症标志物与 TN 的存在和大小之间的关系。
方法
共纳入 133698 名成年人进行当前分析。计算中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）和单核细胞与高密度脂蛋白胆固醇比值（MHR）。采用 logistic 回归探讨这四个标志物与 TN 存在和大小的关系。
结果
女性中 TN 的患病率为 55.1%，男性中为 44%；13%的女性和 8%的男性存在非微结节。在女性中，MHR 和 PLR 与 TN 和非微结节的存在显著相关；在男性中，MHR 和 NLR 与 TN 和非微结节的存在显著相关。
结论
作为一种低成本、简单且可重复的炎症标志物，MHR 与 TN 的存在和大小密切相关，与性别无关。
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