Qinghai Provincial People's Hospital, Xining, China.
Qinghai University, Qinghai, China.
Lipids Health Dis. 2021 Apr 19;20(1):35. doi: 10.1186/s12944-021-01462-4.
BACKGROUND: The inflammatory response plays essential roles in the pathological process and prognosis of Parkinson's disease (PD). This research investigated the predictive value of the neutrophil to high-density lipoprotein ratio (NHR), neutrophil to lymphocyte ratio (NLR), and monocyte to high-density lipoprotein ratio (MHR) for PD. METHODS: Patients with PD (n = 98) were divided into three groups according to disease duration: < 6 years (n = 55), 6-10 years (n = 29) and > 10 years (n = 14). Based on the classification system of Hoehn and Yahr, grades 1 ~ 2.5 were considered early-stage PD (n = 44), and grades 3 ~ 5 were considered advanced-stage PD (n = 54). In addition, healthy subjects (n = 98) matched to the above PD patients in the same period were selected as the control group. Differences in the NHR, NLR, MHR and other indicators among the groups were evaluated. RESULTS: Smoking, drinking, the neutrophil count and the NHR and NLR were remarkably greater and hypertension, index of body mass, the lymphocyte count, and the levels of cholesterol in total, triglycerides, lipoprotein cholesterol with low density and uric acid were sharply lower in the PD group compared with in the control group. Analysis of multifactor logistic regression indicated that the NHR (odds ratio (adjusted OR) = 1.576, 95% CI: 1.053 ~ 2.358, P = 0.027) and NLR (adjusted OR = 1.734, 95% CI: 1.046 ~ 2.876, P = 0.033) were factors of risk for PD, while the MHR was not significantly correlated with PD. The areas under the receiver operating characteristic (ROC) curve (AUCs) for the prediction of PD by the NHR and NLR were 0.654 (95% CI: 0.583 ~ 0.721, P = 0.0001) and 0.69 (95% CI: 0.62 ~ 0.754, P < 0.0001), respectively, and the optimal cutoff values were 1.848 × 10/mmol and 2.62 × 10/mmol. Spearman's correlation analysis indicated that the NHR was correlated with the disease duration significantly negatively and that the MHR was positively correlated with disease severity. CONCLUSIONS: In summary, the NHR not only has strong predictive value for PD but is also closely related to disease duration. The NHR may be a better prediction for the long-period clinical results in PD patients than the MHR and NLR. TRIAL REGISTRATION: Clinical medical reserach center project of Qinghai Province (2017-SF-L1).
背景：炎症反应在帕金森病（PD）的病理过程和预后中起着重要作用。本研究探讨了中性粒细胞与高密度脂蛋白比值（NHR）、中性粒细胞与淋巴细胞比值（NLR）和单核细胞与高密度脂蛋白比值（MHR）对 PD 的预测价值。
方法：将 98 例 PD 患者根据疾病持续时间分为三组：<6 年（n=55）、6-10 年（n=29）和>10 年（n=14）。根据 Hoehn 和 Yahr 分类系统，12.5 级被认为是早期 PD（n=44），35 级被认为是晚期 PD（n=54）。此外，选择同期与上述 PD 患者相匹配的 98 例健康受试者作为对照组。评估各组之间的 NHR、NLR、MHR 和其他指标的差异。
结果：与对照组相比，PD 组吸烟、饮酒、中性粒细胞计数及 NHR 和 NLR 显著增加，而高血压、体重指数、淋巴细胞计数、总胆固醇、甘油三酯、低密度脂蛋白胆固醇和尿酸水平明显降低。多因素 logistic 回归分析表明，NHR（比值比（调整 OR）=1.576，95%置信区间：1.0532.358，P=0.027）和 NLR（调整 OR=1.734，95%置信区间：1.0462.876，P=0.033）是 PD 的危险因素，而 MHR 与 PD 无显著相关性。NHR 和 NLR 预测 PD 的受试者工作特征（ROC）曲线下面积（AUC）分别为 0.654（95%置信区间：0.5830.721，P=0.0001）和 0.69（95%置信区间：0.620.754，P<0.0001），最佳截断值分别为 1.848×10/mmol 和 2.62×10/mmol。Spearman 相关性分析表明，NHR 与疾病持续时间呈显著负相关，而 MHR 与疾病严重程度呈正相关。
结论：总之，NHR 不仅对 PD 具有较强的预测价值，而且与疾病持续时间密切相关。与 MHR 和 NLR 相比，NHR 可能是 PD 患者更能预测长期临床结果的指标。
试验注册：青海省临床医学研究中心项目（2017-SF-L1）。
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