表达 TMPRSS2 的细胞增强了对 SARS-CoV-2 的分离。
Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.
机构信息
Department of Virology 3, National Institute of Infectious Diseases, Tokyo 162-8640, Japan;
Department of Virology 3, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
出版信息
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7001-7003. doi: 10.1073/pnas.2002589117. Epub 2020 Mar 12.
A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.
一种新型的β冠状病毒，即严重急性呼吸综合征冠状病毒 2（SARS-CoV-2），于 2019 年 12 月在中国武汉引发了大规模呼吸道疫情，目前正在全球许多国家蔓延。在这里，我们表明，表达 TMPRSS2 的 VeroE6 细胞系对 SARS-CoV-2 感染高度敏感，使其可用于分离和繁殖 SARS-CoV-2。我们的结果表明，与 SARS-CoV 和中东呼吸综合征-CoV 一样，SARS-CoV-2 感染可被 TMPRSS2 增强。
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