Klongthalay Suwit, Suriyaprom Kanjana
Faculty of Medical Technology, Rangsit University, Phaholyothin Road, Pathumthani 12000, Thailand.
Ethiop J Health Sci. 2020 Mar;30(2):199-208. doi: 10.4314/ejhs.v30i2.7.
The prevalence of metabolic syndrome (MS) has been continually increasing in developing countries especially in Thailand. Although insulin resistance and central obesity are initially considered as significant risk factors, the other causal factors leading to the development of MS continue to challenge the investigators. The aims of this study were to evaluate the prevalence of MS in Pathum Thani province, Thailand and to investigate the relationship between MS and risk factors.
This cross-sectional study was performed with 202 Thai volunteers. Anthropometric-biochemical variables and blood pressures in each subject were measured.
Almost one-third (32.7%) of the participants were diagnosed with MS based on the harmonized criteria, and one of the most significant risk factors is the elevated blood pressure. Weight, BMI, waist and hip circumferences, waist-hip ratio, blood pressure, glucose, triglycerides and uric acid were significantly higher in subjects with MS subjects. However, HDL-C levels were significantly lower in subjects with MS, compared to subjects without MS (p<0.001). The results of regression model after adjustment for age and gender showed that the increased serum uric acid level (OR=1.31, 95%CI: =1.04-1.66), cigarette smoking (OR=3.72, 95%CI: =1.51-9.15) and physical activity (OR=0.36, 95%CI: =0.19-0.67) were significantly related to MS.
These findings suggest that the decrease of uric acid level, the promotion of physical activity and smoking cessation may decrease the risk of developing MS among Thais.
代谢综合征（MS）在发展中国家，尤其是泰国的患病率持续上升。尽管胰岛素抵抗和中心性肥胖最初被视为重要危险因素，但导致MS发生的其他致病因素仍不断给研究人员带来挑战。本研究旨在评估泰国巴吞他尼府MS的患病率，并调查MS与危险因素之间的关系。
对202名泰国志愿者进行了这项横断面研究。测量了每位受试者的人体测量学 - 生化变量和血压。
根据统一标准，近三分之一（32.7%）的参与者被诊断为患有MS，其中最重要的危险因素之一是血压升高。MS患者的体重、BMI、腰围和臀围、腰臀比、血压、血糖、甘油三酯和尿酸显著更高。然而，与无MS的受试者相比，MS患者的高密度脂蛋白胆固醇（HDL-C）水平显著更低（p<0.001）。在对年龄和性别进行调整后的回归模型结果显示，血清尿酸水平升高（OR=1.31，95%CI：=1.04 - 1.66）、吸烟（OR=3.72, 95%CI：=1.51 - 9.15）和身体活动（OR=0.36, 95%CI：=0.19 - 0.67）与MS显著相关。
这些发现表明，降低尿酸水平、促进身体活动和戒烟可能会降低泰国人患MS的风险。
