Cibičková Ľ, Langová K, Vaverková H, Kubíčková V, Karásek D
Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, University Hospital, Olomouc, Czech Republic.
Physiol Res. 2017 Jul 18;66(3):481-487. doi: 10.33549/physiolres.933410. Epub 2017 Feb 28.
Hyperuricemia has been described as associated with the risk of development metabolic syndrome; however the relationship between the uric acid level and particular parameters of metabolic syndrome remained unclear. We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their levels of uric acid with parameters of insulin resistance, lipid metabolism, C-reactive protein, anthropometric parameters. We also defined patients with hypertriglyceridemic waist phenotype and compered their uric acid levels with those without this phenotype. We found that levels of uric acid are associated with parameters of metabolic syndrome. Specifically, dyslipidemia characteristic for metabolic syndrome (low HDL-cholesterol and high triglycerides) correlates better with uric acid levels than parameters of insulin resistance. Also waist circumference correlates better with uric acid levels than body mass index. Patients with hypertriglyceridemic waist phenotype had higher levels of uric acid when compared with patients without this phenotype. Serum uric acid levels are even in low levels linearly correlated with parameters of metabolic syndrome (better with typical lipid characteristics than with parameters of insulin resistance) and could be associated with higher cardiovascular risk.
高尿酸血症被认为与代谢综合征的发生风险相关；然而，尿酸水平与代谢综合征特定参数之间的关系仍不明确。我们对833名血脂异常患者进行了一项横断面研究，并将他们的尿酸水平与胰岛素抵抗、脂质代谢、C反应蛋白、人体测量参数等指标进行关联分析。我们还定义了高甘油三酯腰围表型的患者，并将他们的尿酸水平与无此表型的患者进行比较。我们发现尿酸水平与代谢综合征的各项指标相关。具体而言，代谢综合征特有的血脂异常（低高密度脂蛋白胆固醇和高甘油三酯）与尿酸水平的相关性比胰岛素抵抗指标更好。而且腰围与尿酸水平的相关性比体重指数更好。与无高甘油三酯腰围表型的患者相比，有该表型的患者尿酸水平更高。血清尿酸水平即使处于低水平也与代谢综合征指标呈线性相关（与典型脂质特征的相关性优于与胰岛素抵抗指标的相关性），并且可能与更高的心血管风险相关。
