Wang Ningning, Liu Yang, Ma Yanan, Wen Deliang
School of Public Health, Dalian Medical University, Dalian, Liaoning, China.
School of Public Health, China Medical University, Shenyang, Liaoning, China.
Life Sci. 2017 Dec 15;191:122-131. doi: 10.1016/j.lfs.2017.08.023. Epub 2017 Aug 24.
Exercise is beneficial in obesity, however, the debate about the value of high-intensity interval training (HIIT) vs. moderate-intensity continuous training (MICT) has been long lasting. Therefore, here we have compared the possible beneficial effects of two different exercise training regimes in a mouse model of diet-induced obesity (DIO).
Following 7wk. on high fat diet (HFD), ten-week-old male ICR mice (n=30) were assigned to HIIT, distance-matched MICT or remained sedentary for the next 8 constitutive weeks while maintaining the dietary treatments. Age-matched sedentary mice with standard diet were used as a control (n=10). Exercise was performed on a motorized treadmill for 5days a week.
Both modes of exercise ameliorated adiposity and related metabolic dysfunction induced by HFD and sedentary lifestyle, while mice following HIIT exhibited significantly lower body weight, percentage of fat mass and smaller adipocyte size. HIIT was more favorable in preventing liver lipid accumulation by restoring mRNA levels of genes involved in hepatic lipogenesis (SREBP1, ACC1, FAS) and β-oxidation (PPARα, CPT1a, HAD). In addition, HIIT was more efficient in mitigating adipose tissue inflammation and insulin insensitivity, partly dependent on abrogating phosphorylation of JNK/IRS1 (Ser307) pathway. Moreover, only HIIT led to pronounced beige adipocyte recruitment in inguinal subcutaneous adipose tissue.
We conclude that HIIT contribute a more favorable regulation of metabolic dysfunctions in DIO mice compared with MICT.
运动对肥胖有益，然而，关于高强度间歇训练（HIIT）与中等强度持续训练（MICT）价值的争论由来已久。因此，我们在此比较了两种不同运动训练方案在饮食诱导肥胖（DIO）小鼠模型中的可能有益效果。
在高脂饮食（HFD）喂养7周后，将10周龄雄性ICR小鼠（n = 30）分为HIIT组、距离匹配的MICT组，或在接下来的8周组成期内保持久坐，同时维持饮食处理。将年龄匹配的标准饮食久坐小鼠用作对照（n = 10）。每周在电动跑步机上进行5天运动。
两种运动模式均改善了由HFD和久坐生活方式诱导的肥胖及相关代谢功能障碍，而HIIT组小鼠的体重、脂肪量百分比和脂肪细胞大小显著更低。HIIT在通过恢复参与肝脏脂肪生成（SREBP1、ACC1、FAS）和β-氧化（PPARα、CPT1a、HAD）的基因的mRNA水平来预防肝脏脂质积累方面更具优势。此外，HIIT在减轻脂肪组织炎症和胰岛素不敏感性方面更有效，部分依赖于消除JNK/IRS1（Ser307）途径的磷酸化。此外，只有HIIT导致腹股沟皮下脂肪组织中明显的米色脂肪细胞募集。
我们得出结论，与MICT相比，HIIT对DIO小鼠的代谢功能障碍具有更有利的调节作用。
