在Leber遗传性视神经病变早期通过激光散斑血流图观察到视神经乳头微循环增加。
Increased Microcirculation on Optic Nerve Head by Laser Speckle Flowgraphy at Early Stage of Leber Hereditary Optic Neuropathy.
作者信息
Watanabe Toshiki, Mashima Yukihiko, Kigasawa Kazuteru, Mashima Asako, Shimura Masahiko, Hirakata Akito
机构信息
Department of Ophthalmology, Kyorin University, Tokyo, Japan.
Watanabe Eye Clinic, Tokyo, Japan.
出版信息
Neuroophthalmology. 2018 Oct 11;43(6):411-416. doi: 10.1080/01658107.2018.1526956. eCollection 2019 Dec.
Abstract
Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder predominantly affecting young men. Characteristic features of an early stage of LHON are peripapillary telangiectatic microangiopathy with optic disc hyperaemia and swelling of the retinal nerve fibre layers. We evaluated the microcirculation of the optic nerve head (ONH) by laser speckle flowgraphy (LSFG) in a 79-year-old man and a 36-year-old woman with LHON. The ONH microcirculation of the tissue area was markedly increased in the early stage in both patients. LSFG may be a useful noninvasive method to suspect individuals to have an early stage of LHON.
摘要
Leber遗传性视神经病变（LHON）是一种主要影响年轻男性的线粒体疾病。LHON早期的特征性表现为视乳头周围毛细血管扩张性微血管病，伴有视盘充血和视网膜神经纤维层肿胀。我们通过激光散斑血流图（LSFG）对一名79岁男性和一名36岁患有LHON的女性的视神经乳头（ONH）微循环进行了评估。在两名患者的早期，组织区域的ONH微循环均显著增加。LSFG可能是一种用于怀疑个体处于LHON早期阶段的有用的非侵入性方法。
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