Tynan Dominique, Ahmad Kate, Thieben Mark
Department of Neurology, Royal North Shore Hospital, Sydney, North South Wales, Australia.
Fellow of the Royal Australasian College of Physicians, Sydney, North South Wales, Australia.
Neuroophthalmology. 2018 Oct 5;43(6):417-420. doi: 10.1080/01658107.2018.1526957. eCollection 2019 Dec.
Chronic use of ergotamine derivatives has been well described in the literature to cause retroperitoneal, pleural, pericardial and valvular fibrosis. While acute migraine treatment advances have resulted in a reduction of ergotamine derivatives prescribing, they are still considered appropriate for some patients. We report a case of diffuse pachymeningitis with symptomatic right sixth cranial nerve palsy who had a history of long-term Cafergot© suppository use. To the best of our knowledge, this is the first case to temporally associate ergotamine derivatives with pachymeningitis.
长期使用麦角胺衍生物会导致腹膜后、胸膜、心包和瓣膜纤维化，这在文献中已有充分描述。虽然急性偏头痛治疗的进展已使麦角胺衍生物的处方量有所减少，但它们仍被认为适用于某些患者。我们报告了一例弥漫性硬脑膜炎伴右侧第六颅神经麻痹症状的病例，该患者有长期使用卡非麦角（Cafergot©）栓剂的病史。据我们所知，这是第一例在时间上关联麦角胺衍生物与硬脑膜炎的病例。
