Crisafulli Ernesto, Burgazzi Barbara, Majori Maria, Serra Walter, Chetta Alfredo
Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit University of Parma Parma Italy.
Department of Medicine, Respiratory Medicine Unit and Section of Internal Medicine University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona Verona Italy.
Respirol Case Rep. 2020 Mar 8;8(3):e00531. doi: 10.1002/rcr2.531. eCollection 2020 Apr.
Diffuse alveolar haemorrhage (DAH) is a life-threatening syndrome caused by infection, coagulation disorders or autoimmune diseases. We here report the case of an 81-year-old male subject affected by a multifactorial DAH, in which the bleeding was related to the administration of clopidogrel and warfarin, both implicated in the context of a polycythaemia. He developed a severe acute respiratory failure treated with a ventilatory support by means of a continuous positive airway pressure (C-PAP) therapy. An improvement of patient's clinical conditions was observed only after clopidogrel and warfarin discontinuation.
弥漫性肺泡出血（DAH）是一种由感染、凝血障碍或自身免疫性疾病引起的危及生命的综合征。我们在此报告一例81岁男性患者，患有多因素所致的DAH，其出血与氯吡格雷和华法林的使用有关，这两种药物均与真性红细胞增多症有关。他出现了严重的急性呼吸衰竭，通过持续气道正压通气（C-PAP）治疗进行通气支持。仅在停用氯吡格雷和华法林后，患者的临床状况才有所改善。
